Formulation, characterization, and antibacterial testing of cream supplemented with Aloe vera (Aloe vera L.) gel and Nutgrass (Cyperus rotundus L.) rhizome ethanol extract

Sri Mulyani, Salsabila Adzani Rahmadina, Elfi Susanti VH, Sri Retno Dwi Ariani, Suryadi Budi Utomo, Muhammad Hizbul Wathon

Abstract

Various brands and forms offer a wide array of cream-based cosmetic products. However, only some of these products meet safety specifications. Aloe vera and nutgrass, two plants rich in bioactive compounds, possess anti-inflammatory, soothing, and antibacterial properties, making them ideal for health-safe cosmetic formulations. This research was conducted to develop antibacterial cream formulations incorporating these natural additives. The study focused on quality, organoleptic testing, and the formulated cream's antibacterial assessment. The research methodology encompassed several key processes: preparation of Aloe vera gel and nutgrass rhizome ethanol extract, formulation of the cream, quality testing by SNI 16-6069-1999 standards, organoleptic testing as per SNI 01-2346-2006, and antibacterial activity testing using Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922 bacterial strains. Results indicated that the cream formula enriched with Aloe vera gel and nutgrass rhizome ethanol extract meets the standards for skin-lightening creams and exhibits significant antibacterial capabilities. Furthermore, it was observed that the antibacterial effectiveness of the cream increases with the concentration of the nutgrass rhizome ethanol extract. These findings highlight the potential for integrating natural ingredients into modern cosmetic formulations, providing therapeutic and aesthetic benefits. This approach not only ensures compliance with safety standards but also leverages the natural properties of Aloe vera and nutgrass to enhance the product's functionality in skin care applications

Keywords

Cream; aloe vera; Nutgrass rhizome; antibacterial; organoleptic

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References

[1] Y. Yanhendri and Y. S. W. Jenny, "Berbagai bentuk sediaan topikal dalam dermatologi," Cerminan Dunia Kedokt., vol. 39, no. 6, pp. 423–430, 2012.

[2] N. F. Thamrin, "Formulasi sediaan krim dari ekstrak etanol kunyit (Curcuma domesticae. Val) dan uji efektivitas terhadap bakteri Staphylococcus aureus," NASPA J., 2012.

[3] Badan Pengawas Obat dan Makanan (BPOM), "Peraturan kepala badan pengawas obat dan makanan RI no. HM.03.03.1.43.12.14.7870 tentang kosmetika yang mengandung bahan berbahaya," Jakarta, Indonesia, 2014.

[4] P. D. Darbre and P. Harvey, "Paraben esters: Review of recent studies of endocrine toxicity, absorption, esterase and human exposure, and discussion of potential human health risks," J. Appl. Toxicol., vol. 28, no. 5, pp. 561–578, 2008.

[5] National Toxicology Program, "Bioassay of Butylated Hydroxytoluen (BHT) for Possible Carcinogenicity," National Cancer Institute: Carcinogenesis Technical Report Series, 1979.

[6] A. Widyasanti, A. Y. Rahayu, and S. Zein, "Pembuatan sabun cair berbasis virgin coconut oil (VCO) dengan penambahan minyak melati (Jasminum sambac) sebagai essential oil," Jurnal Teknotan, vol. 11, no. 2, pp. 1–10, 2017.

[7] I. L. Tarigan and A. Muadifah, "Senyawa Antibakteri Bahan Alam," Malang, Indonesia: Media Nusa Creative (MNC Publishing), 2022.

[8] L. S. Cobra, "Aktivitas krim ekstrak rimpang kunyit (Curcuma longa Linn) terhadap bakteri Staphylococcus aureus," Doctoral dissertation, Stikes Karya Putra Bangsa Tulungagung, 2018.

[9] N. Widyaningrum, M. Murrukmihadi, and S. K. Ekawati, "Pengaruh konsentrasi ekstrak etanolik daun teh hijau (Camellia sinesis L.) dalam sediaan krim terhadap sifat fisik dan aktivitas antibakteri," Sains Med. J. Kedokt. dan Kesehat., vol. 4, no. 2, pp. 147, 2012, doi: 10.30659/sainsmed.v4i2.371.

[10] N. S. Majid, P. V. Y. Yamlean, and G. Citraningtyas, "Formulasi dan uji efektivitas krim antibakteri ekstrak daun nangka (Artocarpus heterophyllus Lam.) terhadap bakteri Staphylococcus aureus," Pharmacon, vol. 8, no. 1, pp. 225, 2019, doi: 10.35799/pha.8.2019.29257.

[11] E. S. Hartanto and E. H. Lubis, "Pengolahan minuman sari lidah buaya (Aloevera linn.) (Warta IHP/J. AgroBased Industry.)," 2002.

[12] S. B. Ariyani and Hidayati, "Penambahan gel lidah buaya sebagai antibakteri pada sabun mandi cair berbahan dasar minyak kelapa additional oo aloe vera gel as antibactery in liquid bath soap based coconut oil," J. Ind. Has. Perkeb., vol. 13, no. 1, pp. 11–18, 2018.

[13] N. Sulistyani, E. Kurniati, Yakup, and R. A. Cempaka, "Aktivitas antibakteri infusa daun lidah buaya (Aloe barbadensis miller)," Jurnal Penelitian Saintek, vol. 21, no. 2, pp. 121–126, 2016.

[14] P. D. A. E. Al-Snafi, "A review on Cyperus rotundus a potential medicinal plant," IOSR J. Pharm., vol. 6, no. 7, pp. 32–48, 2016, doi: 10.9790/3013-06723248.

[15] Murnah, "Pemeriksaan Kualitatif dan Kuantitatif Minyak Atsiri dan Tannin dalam Umbi Teki," Jurnal Kedokteran Diponegoro, vol. 30, pp. 3–4, 1995.

[16] I. M. Kusuma, S. Aunillah, and Y. S. Djuhariah, "Formulasi krim lulur scrub dari ekstrak etanol ubi jalar ungu (Ipomoea batatas (L.) Lam.) dan serbuk beras putih (Oryza sativa L.)," J. Farm. Udayana, vol. 10, no. 2, p. 177, 2021, doi: 10.24843/jfu.2021.v10.i02.p12.

[17] A. Wulandari, "Uji aktivitas antioksidan, antiaging, dan penghambatan enzim tirosinase dari ekstrak metanol daun kelor (Moringa oleifera) secara in vitro," Skripsi, Universitas Ahmad Dahlan, 2018.

[18] A. Garg, S. G. Aggarwal, and A. K. Sigla, "Spreading of semisolid formulation; an update," Pharm. Tecnol. North America, vol. 26, no. 9, pp. 84, 2002.

[19] R. A. Bara, G. D. Kandou, A. R. B. Ola, and J. Posangi, "Analisis senyawa antibiotik dari jamur simbion yang terdapat dalam ascidia didemnum mole di sekitar perairan bunaken-sulawesi utara," J. LPPM Bid. Sains dan Teknol., vol. 2, no. 2, pp. 28–35, 2015. [Online]. Available: https://ejournal.unsrat.ac.id/index.php/lppmsains/article/view/10688

[20] G. F. Brooks, J. S. Bute, and S. A. Morse, Jawetz, Melnick, & Adelberg's Mikrobiologi Kedokteran, 23rd ed. New York: McGraw-Hill Companies Inc., 2004.

[21] M. T. Putri, "Identifikasi kandungan senyawa dan aktivitas antibakteri minyak atsirih sereh wangi (Cymbopogon nardus) terhadap bakteri Staphylococcus aureus dan Escherichia coli," Antimicrob. Agents Chemother., vol. 58, no. 12, pp. 7250–7257, 2014.

[22] R. Dewi and Marniza E., "International Standard of Serial Number 2622-1020 Resmila Dewi," J. Saintek Lahan Kering, vol. 2, no. 2, pp. 61–62, 2019. [Online]. Available: https://doi.org/10.32938/slk.v2i2.888

[23] R. Ningtyas, "Uji antioksidan dan antibakteri ekstrak air daun kecombrang (Etlingera elatior (Jack) R.M. Smith) sebagai pengawet alami terhadap Eschercia Coli dan Staphylococcus aureus," Skripsi, 2010, pp. 24–25.

[24] J. H. Hamman, "Composition and applications of Aloe vera leaf gel," Molecules, vol. 13, no. 8, pp. 1599–1616, 2008, doi: 10.3390/molecules13081599.

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