Influence of Contact Time on Loading 99Mo(n,γ) with Alumina Column in 99Mo / 99mTc Generator

Sulaiman Sulaiman, Yono Sugiharto, Gatot Setiawan, Chairuman Chairuman, Adang H.G.


Alumina is usually used for 99Mo absorbers obtained from 235U fission product because the use of 235U is getting limited, and as an alternative 99Mo obtained from natural MoO3 irradiation was used. The problem is that 99Mo produced was not carrier-free as 99Mo from 235U fission product because not all MoO3 is activated to 99Mo, then it is necessary to know the effect of contact time when loading 99Mo into the alumina column. To find out the effect of contact time, the experiment was carried out using 99Mo pH 4, acid alumina column, contact time was varied between 1 to 60 minutes with interval of 15 minutes, and the column was eluted using 2 kinds of eluent namely 0.9% NaCl and MEK. The elution of 99Mo/99mTc generator is performed 3 times, days 1, 2 and 3. The results showed that the performance of alumina in absorbing 99Mo influenced by time. The optimal contact time is 15 minutes for 0.9% NaCl solution and 45 minutes for MEK. The amount of 99Mo breakthrough (µCi99Mo/mCi99mTc) from the alumina column increases with elution time both using 0.9% NaCl or MEK. The 99mTc eluate obtained from this study does not meet standard requirements. The use of a tandem column is needed to prevent 99Mo breakthrough on the 99Mo/99mTc generator to get the 99mTc which meet standard requirement.


99Mo; 99mTc; natural MoO3; acid alumina; contact time; 0.9% NaCl; MEK

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F. Mirjalili, L. Chuah, & H. Mohamad, “Effect of stirring time on synthesis of ultra fine α-Al 2O 3 powder by a simple sol-gel method,” J. Ceram. Process. Res., vol. 12, no. 6, pp. 738–741, 2011.

Y. R. Uhm, Y. H. Oh, G.-H. Lee, M. K. Lee, & C. K. Rhee, “High functional adsorbent alumina nanofibers prepared by a hydrolysis of Al nanopowder.,” Diffus. Defect Data--Solid State Data, Pt. B Solid State Phenom., vol. 119, no. Nanocomposites and Nanoporous Materials, pp. 171–174, 2007.

I. Saptiama & E. Sarmini, “Aktivasi Neutron dari Molibdinum Alam untuk Memperoleh Teknesium-99m (99m Tc),” Urania, vol. 22, no. No.2, pp. 121–132, 2016.

I. Saptiama, H. Herlina, E. Sarmini, S. Sriyono, H. Lubis, H. Setiawan, Marlina, & A. Mutalib, “Optimasi Penyerapan Molib-denum-99 pada Material Berbasis Zirkonium (MBZ),” in Proseding Seminar Nasional Sains dan Pendidikan Sains IX, Fakultas Sains dam Matematika, 2014, pp. 615–620.

H. Salehi, E. Mollarazi, H. Abbasi, & M. Zoghi, “A New 99m Tc Generator using Cerium ( IV ) Oxide as an Adsorbent,” vol. 4, no. 4, pp. 245–249, 2008.

U. N. Sholikhah, E. Sarmini, H. Herlina, H. Lubis, & K. Kadarisman, “Karak-teristik Polimer Zirkonium sebagai adsorben generator 99 mo/99m Tc untuk radiofarmaka diagnostik,” Widya-riset, vol. 2, no. 1, pp. 17–26, 2016.

I. Saptiama, E. Sarmini, & R. Awaludin, “Pengembangan Material Berbasis Zirkonium ( Mbz ),” Semin. Nas. SDM Teknol., no. November, pp. 472–476, 2011.

S. V. Selivanova, E. Lavallée, H. Senta, L. Caouette, J. A. Sader, E. J. van Lier, A. Zyuzin, J. E. van Lier, B. Guérin, E. Turcotte, & R. Lecomte, “Radioisotopic Purity of Sodium Pertechnetate 99mTc Produced with a Medium-Energy Cyclotron: Implications for Internal Radiation Dose, Image Quality, and Release Specifications,” J. Nucl. Med., vol. 56, no. 10, pp. 1600–1608, 2015.

V. So Le, “99mTc Generator Develop-ment: Up-to-Date 99mTc Recovery Technologies for Increasing the Effec-tiveness of 99Mo Utilisation Van,” Sci. Technol. Nucl. Install., vol. 2014, pp. 1–41, 2014.

I. Saptiama, E. Lestari, E. Sarmini, H. Lubis, Marlina, & A. Mutalib, “Develop-ment of 99Mo/99mTc Generator System for Production of Medical Radionuclide 99mTc using a Neutron-activated 99Mo and Zirconium Based Material (ZBM) as its Adsorbent,” Atom Indones., vol. 42, no. 3, pp. 115–121, 2016.

S. C. van der Marck, A. J. Koning, & K. E. Charlton, “The options for the future production of the medical isotope 99Mo,” Eur. J. Nucl. Med. Mol. Imaging, vol. 37, no. 10, pp. 1817-1820, 2010.

V. N. Richards, E. Mebrahtu, & S. E. Lapi, “Cyclotron Production of 99mTc using 100Mo2C targets,” Nucl. Med. Biol., vol. 40, no. 7, 2013.

I. Kambali, “Comprehensive Theoretical Studies on 11-MeV Proton Based Tc-99m Production,” vol. 21, no. 3, pp. 125–130, 2017.

S. Sulaiman, Y. Sugiharto, C. Chairuman, G. Setiawan, & A. H. Gunawan, “Optimasi pH Alumina dan 99 Mo Dalam Pembuatan Generator 99 Mo/99mTc Berbasis MoO3 Alam,” Urania, vol. 24, no. 2, pp. 73–14, 2018.

H. G. Adang, S. Yono, & W. Widyastuti, “Pengaruh Regenerasi Kolom Alumina Asam Terhadap Recovery dan Kualitas 99mTc Hasil Ekstraksi Pelarut MEK dari 99Mo Hasil Aktivasi Neutron,” Urania J. Ilm. Daur Bahan Bakar Nukl., vol. 22, no. 3, pp. 179–188, 2017.

J. Catasus, Y. L. Arias, R. G. Marrero, A.A. Diaz, & J. I. B. Portelo, "Evaluation of TBP, TOA and MEK as Extractans Obtain 99mTC Radiotracers in Organic Phase from 99Mo/99mTC Generator," Nucleus N51. Cuba: 28. pp. 26-31, 2012.

M. Marlina, S. Sriyono, E. Lestari, A. Abidin, H. Setiawan, & K. Kadarisman, “Desain dan Performa Prototipe Generator 99Mo/99mTc dengan Kolom Material Berbasis Zirkonium dan Kolom Alumina,” J. Kim. dan Kemasan, vol. 38, no. 2, p. 93, 2016.


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