Synthesis, Characterization, Hirshfeld Surface Analysis, and Antibacterial Properties of Complex [Ni(4-aminopyridine)4Cl2]·H2O

Putri Dwi Lestari, Nani Farida, Husni Wahyu Wijaya, I Wayan Dasna

Abstract

The reaction between NiCl₂·H₂O and 4-aminopyridine (4-NH₂py) in methanol solvent with a molar ratio of 1:4 successfully produced [Ni(4-aminopyridine)₄Cl₂]·H₂O complex crystallized as blue block-shaped crystals. The single crystal was synthesized using a solvothermal method at 68 °C for 15 hours. The crystal was characterized by melting point determination, Fourier Transform Infrared (FTIR) spectroscopy, molar conductance measurement, and single-crystal X-ray diffraction (SC-XRD) analysis. The complex [Ni(4-NH₂py)₄Cl₂]·H₂O is a monomeric complex with a distorted octahedral geometry. The central Ni(II) ion is coordinated by four 4-NH₂py ligands through the pyridine nitrogen atoms and two chloride anions, while one H₂O molecule is located outside the coordination sphere. The complex crystallizes in a monoclinic lattice system with space group P2₁/n (a = 9.7665(4) Å, b = 17.5841(7) Å, c = 14.0100(6) Å, α = γ = 90°, β = 92.085(2)°) with an R-value of 0.0459. Intermolecular N–H···Cl and H···O interactions are found to be dominant in the structure based on hirshfeld surface analysis. The antibacterial activity of the complex shows higher effectiveness against Escherichia coli (9.18 mm) than Staphylococcus aureus (7.99 mm), representing Gram-negative and Gram-positive bacteria, respectively.

Keywords

4-aminopyridine; antibacterial agent; crystal structure; Ni(II) complex; solvothermal.

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DOI: https://doi.org/10.20961/alchemy.22.2.112417.492-503

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