Formulation and Stability of Miana Leaf Extract Spray Gel with Antioxidant

Nelly Suryani, Rosa Adelina, Vivi Anggia, Tania Sabarini, Sabrina Dahlizar, Ofa Suzanti Betha, Estu Mahanani Dhilasari

Abstract

The extract of Miana leaves (Coleus scutellarioides L.) is recognized for possessing potent antioxidant Action. This research aimed to develop a physically stable spray gel incorporating miana leaf extract and to evaluate its antioxidant potential through the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method. Three formulations with different proportions of Carbopol and hydroxypropyl methylcellulose (HPMC) were evaluated for stability under room-temperature storage and during cycling tests, with organoleptic characteristics and viscosity as assessment parameters. The extract alone exhibited very strong antioxidant Action (IC₅₀ = 47.71 ppm). In comparison, the spray gel formulations showed IC₅₀ values of 141.18 ppm (FE1, 1%), 113.72 ppm (FE2, 3%), and 80.90 ppm (FE3, 5%), corresponding to moderate, moderate, and strong Action, respectively. Among these, FE2 (3% extract) demonstrated the most favorable physical stability.

Keywords

antioxidants; carbopol; DPPH; HPMC; Miana leaves; spray gel.

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DOI: https://doi.org/10.20961/alchemy.22.1.100561.%25p

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