Korelasi Kadar Asam Urat dan High-Mobility Group Box 1 Serum dengan Keparahan Stenosis Arteri Koroner Pasien Sindrom Koroner Akut: Tinjauan Sistematis

Diding Heri Prasetyo, Sally Aman Nasution, Idrus Alwi, Murdani Abdullah

Abstract

Pendahuluan: Sindrom koroner akut (SKA) adalah gangguan yang mengancam jiwa yang tetap menjadi sumber morbiditas dan mortalitas yang tinggi meskipun ada kemajuan dalam pengobatan. Asam urat dan high-mobility group box 1 (HMGB1) keduanya berperan penting dalam patofisiologi SKA, tetapi interaksi kooperatif antara keduanya dalam kejadian keparahan stenosis arteri koroner pada SKA, belum sepenuhnya jelas.  Penelitian ini bertujuan untuk melakukan tinjauan sistematis maupun meta analisis untuk mensintesis hasil-hasil penelitian yang berbeda tersebut agar diperoleh data baru yang bersifat kuantitatif dan lebih akurat.  

Metode: Protokol penelitian didaftarkan dengan PROSPERO (CRD42020210948) dan tinjauan sistematis mengikuti pedoman preferred reporting items for systematic reviews and meta-analyses (PRISMA), dengan menelusuri studi yang dipublikasikan dalam rentan waktu dari Januari 2010 hingga Mei 2020. Cochrane Library, Ebsco, Medline/PubMed, ProQuest dan Sience Direct adalah sumber dari studi yang dipublikasikan. Meta-analisis dilakukan untuk mensintesis korelasi antara kadar asam urat dan HMGB1 serum dan keparahan stenosis arteri koroner. Heterogenitas dinilai menggunakan I2, dan meta analisis menggunakan perangkat lunak Comprehensive Meta Analysis Version 3 (CMA3).

Hasil: Lima studi (n = 601 pasien) diidentifikasi didapatkan korelasi antara kadar asam urat serum dan skor Gensini (r = 0,548; p <0,001) pada pasien SKA. Sedangkan, korelasi antara kadar HMGB1 serum dan skor Gensini pada pasien SKA didapatkan satu studi (n = 60 pasien) dengan nilai r = 0,588; p <0,001. Bias heterogenitas ditemukan dalam analisis, sedangkan bias publikasi tidak ditemukan.

Kesimpulan: Keparahan stenosis arteri koroner pada pasien dengan SKA berkorelasi positip dengan kadar asam urat dan HMGB1 serum.

Keywords

Asam urat; HMGB1; sindrom koroner akut; skor Gensini

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References

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DOI: https://doi.org/10.13057/smj.v4i1.48046

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