Left Ventricular Hypertrophy dan Fungsi Ginjal pada Penderita Hipertensi

HERU SULASTOMO, FADLAN AKHYAR FAUZI, RATNA KUSUMAWATI

Abstract

Introduction: Chronic hypertension can cause complication such as left ventricular
hypertrophy (LVH).  LVH can lead renal artery vasoconstriction, impaire blood perfusion
to glomerulus and change glomerulus filtration coeficient. The aim of this study was to
compare kidney function between hypertensive patient with LVH and without LVH
Methods: This was a case control study that conducted at Dr. Moewardi General
Hospital Surakarta. All subjects has been diagnosed as hypertension more than 5 years.
The diagnosis of LVH was based on electrocardiography (ECG) result. Kidney function
was assessed based on serum ureum, creatinin, and uric acid  levels.
Results: The subject of this study was 26 hypertension patients with LVH and 13
hypertension patients without LVH. Serum ureum level in patients with LVH was higher
than hypertension patients without LVH(24.92 ± 7.99 Vs 32.33±9.91, p= 0.004). Serum
uric acid level in hypertension patients with LVH was higher compare to hypertension
patients without LVH as well (5.26 ± 1.15 Vs 6.98 ± 1.83, p= 0.029). Whereas serum
creatinine levels were not significantly different between two groups of subjects.  
Sulastomo et.al., Left Ventricular Hypertrophy dan Fungsi Ginjal pada Penderita Hipertensi
Conclusion: : Serum ureum and uric acid levels in hypertensive subjects with LVH are
higher than subjects without LVH. There is no difference between serum creatinin level in
hypertensive subject with LVH and without LVH.


Keywords

left ventricular hypertrophy; serum ureum; serum uric acid; serum creatinine

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DOI: https://doi.org/10.13057/smj.v1i2.28712

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