Left Ventricular Hypertrophy dan Fungsi Ginjal pada Penderita Hipertensi



Introduction: Chronic hypertension can cause complication such as left ventricular
hypertrophy (LVH).  LVH can lead renal artery vasoconstriction, impaire blood perfusion
to glomerulus and change glomerulus filtration coeficient. The aim of this study was to
compare kidney function between hypertensive patient with LVH and without LVH
Methods: This was a case control study that conducted at Dr. Moewardi General
Hospital Surakarta. All subjects has been diagnosed as hypertension more than 5 years.
The diagnosis of LVH was based on electrocardiography (ECG) result. Kidney function
was assessed based on serum ureum, creatinin, and uric acid  levels.
Results: The subject of this study was 26 hypertension patients with LVH and 13
hypertension patients without LVH. Serum ureum level in patients with LVH was higher
than hypertension patients without LVH(24.92 ± 7.99 Vs 32.33±9.91, p= 0.004). Serum
uric acid level in hypertension patients with LVH was higher compare to hypertension
patients without LVH as well (5.26 ± 1.15 Vs 6.98 ± 1.83, p= 0.029). Whereas serum
creatinine levels were not significantly different between two groups of subjects.  
Sulastomo et.al., Left Ventricular Hypertrophy dan Fungsi Ginjal pada Penderita Hipertensi
Conclusion: : Serum ureum and uric acid levels in hypertensive subjects with LVH are
higher than subjects without LVH. There is no difference between serum creatinin level in
hypertensive subject with LVH and without LVH.


left ventricular hypertrophy; serum ureum; serum uric acid; serum creatinine

Full Text:



World Health Oganization (WHO). A global brief on Hypertension : Silent killer, global public health crisis. Jenewa: WHO; 2013. http://www.who.int/topics/hypertension/en/ diakses April 2017.

Kementerian Kesehatan Republik Indonesia (Kemenkes RI). Riset Kesehatan Dasar (Riskesdas) 2018. Jakarta: Kemenkes RI; 2018.

Nadar SK, Tayebjee MH, Messerli F, Lip GYH. Target organ damage in hypertension: pathophysiology and implications for drug therapy. Curr Pharm Des 2006; 12(13):1581–1592.

Ramli A, Ahmad NS, Paraidathathu T. Medicationadherence among hypertensive patients of primary health clinics in Malaysia. Patient Prefer and Adherence 2012; 6:613–622.

Abegaz TM, Tefera YG, Abebe TB. Target organ damage and long term effect of nonadherence to clinical practice guidelines in patients with hypertension: a retrospective cohort study. Int J Hypertens 2017; 2017:1-8.

Shi HT, Wang XJ, Li J, Song GF, Huang ZY, Guo XY, dkk. Association of Left Ventricular Hypertrophy with a faster rate of renal function decline in elderly patients with non-end-stage renal disease. J Am Heart Assoc 2015; 4(11): 1-7.

Mensah GA. Hypertension and target organ damage: Don’t believe everything you think!. Ethn Dis 2016; 26(3): 275-78.

Sudoyo AW, Alwi I, Setiati S, Setiyohadi B, Simadibrata M (2009). Buku Ajar Ilmu Penyakit Dalam Jilid 1, edisi 5. Jakarta: Interna Publishing.

Kahan T, Bergfelt L. Left ventricular hypertrophy in hypertension: Its Arrhythmogenic potential. Heart 2005; 91: 250-256.

Gowda S, Desai PB, Kulkarni SS, Hull VV, Math AAK, Vernekar SN. Markers of renal function test. North Am J Med Sci 2010; 2:170-173.

Pinto E. Blood pressure and ageing. Postgrad Med J 2007; 83:109-114

Lionakis N, Mendrinos D, Sanidas E, Favatas G, Georgopoulou M. Hypertension in the elderly. World J Cardiol 2012; 4(5) 135-147.

Palacios S, Henderson VW, Siseles N, Tan D, Villaseca P. Age of menopause and impact of climacteric symptoms by geographical region. Climacteric, 13(5) : 419-428.

Ashraf MS, Vongpatanasin W. Estrogen and hypertension. Curr Hypertens Rep 2006;8(5):368-376.

Li W, Wang D, Wu C, Shi O, Zhou Y, Lu Z. The effect of boody mass index and physical activity on hypertension among Chinese middle-aged and older population. Sci Rep 2018;7: 1-7.

Dua S, Bhuker M, Sharma P, Dhall M, Kapoor S. Body mass index relates to blood pressure amomg adults. N Am J Med Sci 2014;6(2): 89-95.

Banfi G, Del F. Serum creatinine values in elite athletes competing in 8 different sports: comparison with sedentary people. Clin Chem 2006; 52: 330–331.

Salazar J H. Overview of Urea and creatinin. Lab medicine 2014; 45(1): e19-e20.

Giordano C, Karasik O, King-Morris K, Asmar A. Uric acid as a marker of kidney disease: review of current literature. Dis Markers 2015: 1-7.

Johnson RJ, Segal MS, Srinivas T, Ejaz A, Mu W, Roncal C, dkk. Essential hypertension, progressive renal disease, and uric acid: a pathogenetic link? J Am Soc Nephrol 2005; 16(7): 1909–1919.

Ravera M, Noberasco G, Signori A, Re M, Filippi A, Cannavo R, dkk. Left-ventricular hypertrophy and renal outcome in hypertensive patients in primary-care. Am J Hypertens. 2013;26(5): 700-707


  • There are currently no refbacks.