Review Potensi Daun Awar-awar Sebagai Agen Ko-Kemoterapi Antimetastasis Kanker Payudara

Dhiya Ulhaq Salsabila, Syifa Athia Zainun Faqiha, Afivah Dewi Anggraeni, Muthi' Ikawati

Abstract

Kematian akibat kanker payudara sebagian besar disebabkan oleh metastasis. Kemoterapi sebagai agen terapi kanker payudara juga menimbulkan efek samping metastasis. Daun awar-awar (Ficus septica Burm. F.) mengandung senyawa golongan alkaloid fenantroindolisidin. Ekstrak daun awar-awar dan alkaloid fenantroindolisidinnya berefek sitotoksik pada sel kanker payudara dan sinergis terhadap agen kemoterapi. Artikel ini mengulas potensi daun awar-awar sebagai agen pendamping kemoterapi (ko-kemoterapi), khususnya melalui mekanisme antimetastasis. Aktivitas sitotoksik daun awar-awar pada sel kanker terjadi melalui peningkatan apoptosis dan modulasi siklus sel. Daun awar-awar menghambat metastasis sel kanker payudara dengan menurunkan ekspresi VEGF, MMP-9, dan Rac-1 yang terlibat dalam metastasis. Oleh karena itu, dapat disimpulkan bahwa daun awar-awar berpotensi untuk dikembangkan sebagai agen ko-kemoterapi antimetastasis untuk kanker payudara. 

Keywords

alkaloid fenantroindolisidin; daun awar-awar (Ficus septica Burm. F.); kanker payudara; ko-kemoterapi; metastasis

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References

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DOI: https://doi.org/10.20961/jpscr.v6i3.45180

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