Transport Test Through Shed Snake Skin Membrane of Doble Emulsion Formula of Strawberry Fruits (Fragaria vesca L.)
Abstract
Abstract: Anthocyanin was a dominant flavonoids component in
strawberries fruits that have antioxidant activity, however tend to have low
stability and permeation into the skin. Double emulsions were choised
because they were able to protect and enhance the release of bioactive
components through the skin, so much used in the cosmetics industry.
This research would formulation a double emulsion of water/oil/water
of strawberry fruits. The w/o primer emulsion consists of strawberry fruits as
a bioactive component, combination of emulgator : span 80, croduret 50 ss,
and propylene glycol, and the isopropyl myristist as oil phase. Water/oil
emulsion has a low viscosity and less comfortable when used topically, so it
needs to be dispersed into the gel matrix to facilitate its application and could
assist the permeation of the strawberry bioactive component into the stratum
corneum. The strawberry double emulsion formula then carried out by the
transport test through the shed snake skin membrane using a Franz-model
diffusion cell with the parameter of cumulative flavonoid weight which
capable of passing through the membrane.
The double-emulsion formulation have a pink color, smell of
strawberries, and a thick consistency and were easily applied. The physical
stability parameters of the doble emulsion formulation : pH 6.52; broad area
of 10.2 cm²; Sticking 1.87 seconds. The color of the strawberry fruit doble
emulsion formula changed brown after undergoing stress testing with
flavonoid content decreased by 85%. The cumulative amount of flavonoid
transported across the shed snake skin membrane was 117.14 μg/cm² during
5 hours. The permeability of the shed snake skin membrane was 2.84x10-5
μg/cm² and the flux value was 6.6x10-5
μg/sec.
Key words: doble emulsion water/oil/water, flavonoids, transport
through membrane, shed snake skin
strawberries fruits that have antioxidant activity, however tend to have low
stability and permeation into the skin. Double emulsions were choised
because they were able to protect and enhance the release of bioactive
components through the skin, so much used in the cosmetics industry.
This research would formulation a double emulsion of water/oil/water
of strawberry fruits. The w/o primer emulsion consists of strawberry fruits as
a bioactive component, combination of emulgator : span 80, croduret 50 ss,
and propylene glycol, and the isopropyl myristist as oil phase. Water/oil
emulsion has a low viscosity and less comfortable when used topically, so it
needs to be dispersed into the gel matrix to facilitate its application and could
assist the permeation of the strawberry bioactive component into the stratum
corneum. The strawberry double emulsion formula then carried out by the
transport test through the shed snake skin membrane using a Franz-model
diffusion cell with the parameter of cumulative flavonoid weight which
capable of passing through the membrane.
The double-emulsion formulation have a pink color, smell of
strawberries, and a thick consistency and were easily applied. The physical
stability parameters of the doble emulsion formulation : pH 6.52; broad area
of 10.2 cm²; Sticking 1.87 seconds. The color of the strawberry fruit doble
emulsion formula changed brown after undergoing stress testing with
flavonoid content decreased by 85%. The cumulative amount of flavonoid
transported across the shed snake skin membrane was 117.14 μg/cm² during
5 hours. The permeability of the shed snake skin membrane was 2.84x10-5
μg/cm² and the flux value was 6.6x10-5
μg/sec.
Key words: doble emulsion water/oil/water, flavonoids, transport
through membrane, shed snake skin
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