The Effect of Melatonin on Platelet Levels in Wistar Rat After Burns in Two Days
Abstract
Methods : This is experimental study with a sample of 12 Wistar rats that matched the inclusion and exclusion criteria. Rats were divided into two groups, namely K1 as control and K2 as a group that was given melatonin at a dose of 10 mg/kg. Platelet levels were measured at T1 (0th hour post burn), T2 (24th hour post burn), and T3 (48th hour post burn). The data were analyzed by the Shapiro-Wilk normality test, followed by Parametric Paired t-Test and the Independent t-Test.
Result : This experimental results there was a significant increase in the number of platelets between T2 and T3 and between T1 and T3 in control group. And in K2, there was a significant decrease in the number of platelets between T1 and T2 and between T2 and T3. Meanwhile, between T1 and T3 there was a significant increase in platelet levels.
Conclusion: Melatonin can significantly increase the platelet levels of burn Wistar rats at 48 hours post-burn.
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