Profil Laboratorium Ibu Hamil dengan COVID-19 di Rumah Sakit UNS

Hafi Nurinasari, Nurhasan Agung Prabowo, Asih Anggraeni, Syahrini Wisdayanti, Sri Sulistyowati

Abstract

Pendahuluan:

Kasus ibu hamil dengan kondisi COVID-19 terjadi perubahan sistem imun dan luaran kehamilan. Pasien kehamilan dengan COVID-19 membutuhkan tatalaksana yang khusus. Tujuan penelitian untuk mengetahui profil laboratorium ibu hamil dengan COVID-19  di Rumah Sakit UNS.

Metode:

Penelitian yang dilakukan bersifat observasional analitik. Rancangan penelitian yang digunakan adalah cohort retrospektif. Penelitian ini dilakukan di Rumah Sakit UNS Sukoharjo mulai dari bulan Januari sampai Februari  2021. Kriteria inklusi adalah ibu hamil dengan suspek COVID-19. Data klinis dan laboratorium dibandingkan antara kelompok COVID-19 dan non COVID-19. Uji statistik menggunakan uji t independent dan uji chi square. P bermakna jika p <0,05.

Hasil: Dari  32 pasien ibu hamil suspek COVID-19, 18 terdiagnosis Non COVID-19 dan 14 pasien COVID-19. Rerata usia adalah Non COVID-19 adalah 30,33+6,62 tahun, pasien COVID-19 31,36+6,57. Peningkatan leukosit lebih banyak didapatkan pada pasien Non COVID-19 (p=0,01), sedangkan neutrofil (p=0,01), NLR (p=0,03) dan lama rawat inap (p=0,01) lebih banyak pada pasien COVID-19 dibandingkan pasien COVID-19..

Kesimpulan: Leukosit, neutrofil, NLR dan lama rawat inap berbeda antara pasien hamil dengan COVID-19 dan Non COVID-19.

Kata Kunci: COVID-19, Kehamilan, leukosit, netrofil, NLR, lama rawat inap.

ABSTRACT

Introduction: In cases of pregnant women with COVID-19 conditions, changes in the immune system and pregnancy outcomes occur. Pregnant patients with COVID-19 need exceptional management. The research objective was to determine the Laboratory Profile for Pregnant Women with COVID-19 at the UNS Hospital.

Method: This research is analytic observational. The research design used was a retrospective cohort. This research was conducted at the UNS Hospital from January to February 2021. The inclusion criteria were pregnant women with suspected COVID-19. We compare Demographic and laboratory data between the COVID-19 and non-COVID-19 groups. Statistical test using independent t-test and chi-square test. P is significant if p <0.05.

Result: Of the 32 pregnant women patients with suspected COVID-19, 18 were diagnosed with Non-COVID-19 and 14 were COVID-19 patients. The mean age was Non COVID-19 was 30.33 + 6.62 years, for COVID-19 patients 31.36 + 6.57. The increase in leukocytes was more found in Non COVID-19 patients (p = 0.01), while neutrophils (p = 0.01), NLR (p = 0.03) and length of stay (p = 0.01) were more in COVID-19 patients versus COVID-19 patients ..

Conclusion: Leukocytes, Neutrophils, NLR, and length of stay differed between pregnant patients  COVID-19 and non-COVID-19.

Keywords: COVID-19, Pregnancy, Leukosit, Netrofil, Neutrophils to lymphocyte ratio, length of stay

Keywords

COVID-19;Kehamilan; leukosit; netrofil; NLR; lama rawat inap

Full Text:

PDF

References

1. Lopez Marta, Gonce Anna, Meller Eva, Plaza Ana, Hernandez Sandra et al (2020). Coronavirus Disease 2019 in Pregnancy: A Clinical Management Protocol and Considerations for Practise. Fetal Diagnosis and Therapy 2020;47:519-528. DOI:10.1159/000508487.

2. Dasraath Pradip, Wong Jin Lin Jeslyn, Lim Mei Xian Karen, Lim Li Min et al (2020). Coronavirus Disease 2019 (COVID-19) pandemic and Pregnancy. American Journal of Obstetrics and Gynecology. 521-531.

3. Rasmunssen Sonja, Smulian John C, Lednicky John A, Wen Tony S, Jamieson Daniese (2020). Coronavirus Disease 2019 (COVID-2019) and Pregnancy : What Obstetricians Need To Know. American Journal of Obstetrics and Gynecology. 415-426.

4. DB, 21 March 2020, ADB approves $3 million grant to support Indonesia'sfight against COVID-1.

5. Putri Ririn Noviyanti (2020). Indonesia dalam Menghadapi Pandemi COVID-19.Jurnal Ilmiah Universitas Batanghari Jambi. 705-709. DOI 10.33087/jiubj.v20i2. 1010.

6. Djalante R. Lassa J, Setiamarga D, Sudjatma A, Indrawan M, Haryanto B, Mahfud

7. G., et al (2020). Review and Analysis of Current Responses to COVID-19 in Indonesia : Period of January to March 2020. Profress in Disaster Science. 100091, 1-9.

8. WHO. 26 March (2020). Critical Preparedness. Readliness and Response Actions for Covid-19.

8. Allotey John, Stallings Elena, Bonet Marcedes. Yap Magnus, et al (2020). Clinical Manifestations, Risk Factor, and Maternal and Perinatal Outcomes of Coronavirus Disease 2019 in Pregnancy: Living Systematic Review and Meta-analysis. BMJ 2020;370:m3320 | doi: 10.1136/bmj.m3320.

9. Himpunan Kedokteran Fetomaternal Indonesia (2020). Rekomendasi Penanganan Infeksi Virus Corona (COVID-19) Pada Maternal (Hamil, Bersalin dan Nifas).

10. Yee Jeong, Kim Woorim, Han Ji Min, Yoon Ha Joung, Lee Nari et al (2020). Clinical Manifestations and Perinatal Outcomes of Pregnant Women with COVID-19 : a Systematic Review and Meta-analysis. Scientific Reports. 10:18126. https://doi.org/10.1038/s41598-020-75096-4.

11. Norooznezhad Amir Hossein, Eskandarion Sonia, Akbari Razieh, Alimohammadi Shohreh, Nabavian Seyedeh Meedeh et al (2020). Changes of Leukocytes, Neutrophils, and Lymphocytes Count and Dependent Variables in Pregnant Women With Coronavirus Disease 2019 Before and After Caesarean Delivery. Journal Medical of Virology; 93; 664 – 666.

12. Ranganathan, P., & Aggarwal, R. (2018). Study designs: Part 1-An overview and classification. Perspectives in Clinical Research. https://doi.org/10.4103/picr.PICR_124_18.

13. Taufiqorochman Mochammad Arief (2016). Pengantar Metodologi Penelitian Ilmu Kesehatan. Sebelas Maret University Press.

14. Masturoh, Imas,. dan T, Nauri Anggita. Metodologi Penelitian Kesehatan. Pusat Pendidikan Sumber Daya Manusia Kesehatan Edisi Tahun 2018.

15. Azab Azab Elsayed, Jbireal J.M., Albasha Mohamed Umar (2020). East African Scholars International Journal of Medical Sciences; Vol-3, Iss-5; 185-192.

16. Ding Xiurong, Yu Yanhua, Lu Bichao. Huo Jianbo, Chen Ming (2020). Dynamic Profile and Clinical Implications of Hematological Parameters in Hospitalized Patients with Coronavirus Disease 2019. Clin Chem Lab Med. 58 (8) : 1365-1371.

17. Nokhostin Fahimeh, Elham Saffarieh, Seyedeh Reyhaneh Yousefi Sharami (2020). Investigating the Effect of Covid-19 on Pregnant Women. Journal of Critical Reviews . Vol 7, Issue 7, 2020.

18. Luo, Y., & Yin, K. (2020). Management of pregnant women infected with COVID-19. The Lancet. Infectious diseases, 20(5), 513–514. https://doi.org/10.1016/S1473-3099(20)30191-2

19. Tan L, Wang Q, Zhang D, Ding J, Huang Q, Tang Y-Q, et al. (2020). Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study. Signal Transduct Target Ther. 2020;5:33. https://doi.org/10.1038/s41392-020-0148-4

20. Huang, Glen., , Alex J. Kovalic , Christopher J. Graber. (2020). Prognostic Value of Leukocytosis and Lymphopenia for Coronavirus Disease Severity. Emerg InfectDis.26(8):1839-1841 https://stacks.cdc.gov/view/cdc/91567

DOI: https://doi.org/10.13057/smj.v4i2.49249

Refbacks

  • There are currently no refbacks.