Biopreparation of Snail Slime (Achatina fulica) with Chitosan Membranes as Wounds Dressing for Wound Healing

Abstract

The aim of this research purposes is biopreparation snail slime on chitosan membrane as a gauze bandage for wound healing in vivo. Snail slime contains substances are achatin isolates, heparan sulfate, and calcium. The content of isolates achatin useful as an antibacterial and anti-inflamation, while calcium plays a role in hemostasis. Chitosan has uses in the field of biomedical and pharmaceutical, among others, chitosan fibers as threads in surgery that can be absorbed by the human body; bandage covering the wound and the carrier medicine. Chitosan are biodegradable, degradable, non-toxic, non-immunogenic to the body tissue of animals. Wound healing is very important to restore the integrity of the skin as soon as possible and is a complex and dynamic process. Phase involving fibroblast cell proliferation is one important step in wound healing. Wound healing with snail slime and chitosan may be an alternative because it has many benefits. Research methods include synthezise non biomembran chitosan glycerol, snail slime isolation, treatment stage in test animals 5 mice are negative control group; snail slime treatment; chitosan membrane; snail slime and chitosan membrane ratio of 1: 1; and a positive control. The results showed synergistic effect of antibacterial and anfiinflamation  snail slime and chitosan is able to accelerate the proliferative phase of wound healing process. Bioprepration snail slime is integrated in biomembran chitosan can be applied as gauze wound dressing that is safe and effective in order to accelerate the wound healing process

Keywords: snail slime, chitosan membrane, wound dressings, healing wound