PRIMARY MEDIASTINAL YOLK SAC TUMOR: A RARE CASE

Fitri Dewi Ismida, Budi Yanti

Abstract

Background. Yolk sac tumor is a subtype of germ cell tumor which is highly malignant. Mediastinal Yolk sac tumor is also an extragonadal germ cell tumor which is extremely rare and is common in children and young adults. We report a case of a Yolk Sac Tumor in the anterior mediastinum in a 21-year-old male patient.

Case. A case of Yolk Sac Tumor in a 21-year-old man with complaints of shortness of breath and chest pain experienced for ± 2 weeks. The CT scan showed the soft tissue with high-density thorax in the anterior mediastinum. The Levels of Alpha Feto Protein (AFP) 2,000 ng / mL and Beta-Human Chorionic Gonadotropin (B-HCG) 1.20 mIU / mL. Macroscopically, it appears brownish-gray tissue with a volume of 0.5 ccs. Typical histopathological examination reveals a Yolk Sac tumor.

Conclusion. Yolk Sac Tumor as a Mediastinal primary tumor is a rare tumor. The diagnosis must be made not only based on histopathological examination but also based on the patient's age and elevated serum alpha-fetoprotein (AFP) and Beta-Human Chorionic Gonadotropin (B-HCG). Despite there is modern chemotherapy, the prognosis for these tumors is highly poor.

Keywords . Yolk sac tumor, mediastinum, germ cell.

Keywords

Yolk sac tumor, mediastinum, germ cell.

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References

Perlman E, Marx A, Bokemeyer C and Wick M. Yolk sac tumour. In: Travis W, Brambilla E, Müller-Hermelink H and Harris C. Editor. Pathology and Genetics of Tumours of Lung, Pleura, Thymus and Heart. World Health Organization Classification of Tumours. Lyon: WHO IARC Press; 2014. p. 207-8.

Nakhla S and Sundararajan S. A Rare Case of Primary Anterior Mediastinalo Yolk Sac Tumour in an Elderly Adult Male. 2016 [cited on 2016, Desember 3rd]. Available from: http://www.hindawi.com/journal

Papaionnou A, Porpodis K, Spyratos D and Zarogoulidis K. Yolk Sac Tumour in The Anterior Mediastinum. 2013 [cited on 2016, Desember 3rd]. Available from: http://Pneumon/Yolk Sac Tumour in The Anterior Mediastinum.

Pathology outlines. Yolk Sac Tumour. 2012 [cited on 2016, Desember 3rd] Alvailable from: http://www.pathologyoutlines.com

Salim S, Harianawala, Vinay K, Sharma, Alan D and Haber. Primary mediastinal Yolk Sac Tumour in 45-year-old Man. 2005 [cited on 2016, Desember 3rd]. Available from: http://journal.publications.chestnet

Orell SR, Sterrett GF and Whitaker D. Bone. In: Fine Needle Aspiration Cytology. 4thed., Elsevier, Philadelphia, p. 265.

Czerniak B, Tuziak T, Kram A, Ayala A. Bone Tumors. In: Koss LG, Melamed MR. (Editor). Koss’ Diagnostic Cytology and Its Histopathologic Bases. Lippincott Williams & Wilkins; Philadelphia; 2006. p. 1355-8.

Crowford JM, Liu C. Mediastinum. In: Kumar R, Abbas A, Lancey AD, Malone E, Editors. Robbins and Contran Pathology Basic of Disease. 8thEd. Philadelphia: Saunders Elvisier; 2011

Suster. Thoracix System. In: Weidner, Cote, Suster and Weiss. Modern pathology. Philadelphia: Saunders Elvisier; 2009. P.480-1.

Pins MR. Thymus and Mediastinum. In: Gattuso P, Reddy VB, David O, Spitz DJ, Haber MH, editors. Differential Diagnosis Surgical Pathology. 2nd ed. Philadelphia: Saunders Elsivier; 2010. p. 303.

Rosai J. Rosai and Ackerman’s Surgical Pathology. Bone and Joint, Mosby; Philadelphia-USA; 2004; p. 2043-6

Yolk Sac Tumour Pathology. 2015 [cited on 2016, Desember 3rd] Alvailable from: http://emedicine.medscape.com.

Acs G and Khurana JS. Mediastinum. In: Cheng L, Bostwick DG. Essensial of Anatomic Pahology. New Jersey:Humanapress; 2002.p. 15-13

Sakurai H, Asamura H, Suzuki K, Watanabe S and Tsuchiya R. Management of Primary Malignant Germ Cell Tumor of the Mediastinum. 2004 [cited on 2016, Desember 3rd] Alvailable from: http://www.jjco.oxfortjournals.org

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