Formulation of Small Quantity Lipid-based Nutrient Supplement (SQ-LNS) Tablet from Soybean: A Preventive Approach on Stunted Birth for Pregnant and Breastfeeding Women

Virginia Heaven Mariboto Siagian, Johnessa Cung, Spica Diani Anandawijaya, Sandya Amelia Febriliani, Avika Widyapuspita, Iyan Sopyan

Abstract

The prevalence of stunting in Indonesia, which has not met the requirements of the WHO, makes stunting a national problem. In line with the nutritional intervention in 2020-2030, UNICEF developed SQ-LNS products as a food paste. As an effort to prevent stunting as well as improve product stability, the formulation of Small-Quantity Lipid-based Nutrient Supplements (SQ-LNS) from soybeans (Glycine max (L.) Merr) in tablet form is proposed to be a solution for pregnant and breastfeeding women. Microencapsulation technology is used to entrap soybean oil as the lipid source of this supplement. This study aims to obtain the best concentration of maltodextrin, soy protein isolate, and carboxymethyl cellulose as a soybean oil coating for felting into SQ-LNS tablet preparation. The best microcapsule is produced from a 40% formula with a percent yield of 28%, encapsulation efficiency of 79.83%, PSD microcapsule of 1.003 μm, and round agglomerated particles with a smooth surface without any residual oil seen under the SEM, and obtained the best formulation and evaluation of SQ-LNS tablets so that they meet the quality standards of good stunting supplement tablets.

Keywords

Soybean; Microencapsulation; SQ-LNS; Stunting; Tablet

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References

Arimond, M., Zeilani, M., dan Jungjohann, S. (2015). Considerations in developing lipid‐based nutrient supplements for prevention of undernutrition: experience from the international lipid‐based nutrient supplements (ilins) project. Maternal and Child Nutrition, 11 (4): pp.31-61. https://doi.org/10.1111/mcn.12049.

Badrya, L., Gunarti, D.R., dan Wulandari, Y. (2024). Superoxide dismutase (sod) activity in stunted children: review article. Science Midwifery, 12(2): pp.983-991. https://doi.org/10.35335/midwifery.v12i2.1581.

Cizmarova, B., Hubkova, B., & Birkova, A. (2023). Quercetin as an effective antioxidant against superoxide radical. Functional Food Science, 3(3): pp.15–25. https://doi.org/10.31989/ffs.v3i3.1076.

Hasrini, R.F., Zakaria, F.R., dan Suparto, I.H. (2017). Mikroenkapsulasi minyak sawit mentah dengan penyalut maltodekstrin dan isolat protein kedelai. Jurnal Teknologi dan Industri Pangan, 28(1): pp.10-19. https://doi.org/10.6066/jtip.2017.28.1.10.

Kanchana, K. (2016). A review on Glycine max (l.) merr. (soybean). Journal of Pharmacy and Pharmaceutical Science, 5(1): pp.356-371. https://doi.org/10.21107/agrointek.v14i1.6311.

Kementerian Kesehatan Republik Indonesia. (1995). Farmakope Indonesia Edisi IV. Jakarta, Kementerian Kesehatan Republik Indonesia.

Kementerian Kesehatan Republik Indonesia. (2014). Farmakope Indonesia Edisi V. Jakarta, Kementerian Kesehatan Republik Indonesia.

Kementerian Kesehatan Republik Indonesia. (2020). Farmakope Indonesia Edisi VI. Jakarta, Kementerian Kesehatan Republik Indonesia.

Kementerian Kesehatan Republik Indonesia. (2023). Prevalensi stunting di indonesia turun ke 21,6% dari 24,4%. Available from: https://sehatnegeriku.kemkes.go.id/baca/rilis-media/20230125/3142280/prevalensi-stunting-di-indonesia-turun-ke-216-dari-244/ [Accessed 14th January 2024].

Khamidah, S.Z., Hastarini, E., Fardiaz, D., dan Budijanto, S. (2017). Mikroenkapsulasi konsentrat asam lemak tak jenuh dari minyak ikan patin, Jurnal Teknologi dan Industri Pangan. 30(2): pp.143-151. https://doi.org/10.6066/jtip.2019.30.2.143.

Khatri, P., Katikaneni, P., Desai, D., dan Minko, T. (2018). Affinisol HPMC polymers for direct compression process applications. Journal of Drug Delivery Science and Technology. 47(1): pp.461-467. https://doi.org/10.1016/j.jddst.2018.08.018.

Ningsih, T.E., Siswanto, dan Winarsa, R. (2018). Aktivitas antioksidan kedelai edamame hasil fermentasi kultur campuran oleh Rhizopus oligosporus dan Bacillus subtilis. Berkala Saintek, 6(1): pp.17-21. https://doi.org/10.19184/bst.v6i1.7556.

Parcheta, M., Świsłocka, R., Orzechowska, S., Akimowicz, M., Choińska, R., Lewandowski, W. (2021). Recent Developments in Effective Antioxidants: The Structure and Antioxidant Properties. Materials (Basel), 14(8): pp.1984. https://doi.org/10.3390/ma14081984.

Peng, Q., Meng, Z., Luo, Z., Duan, H., Ramaswamy, H.S., dan Wang, C. (2023). Effect of emulsion particle size on the encapsulation behavior and oxidative stability of spray microencapsulated sweet orange oil (Citrus aurantium Var. dulcis). Foods, 12(1): pp.116-129. https://doi.org/10.3390/foods12010116.

Purnamayati, L., Dewi, E.N., dan Kurniasih, R.A. (2016). Karakteristik fisik mikrokapsul fikosianin spirulina pada konsentrasi bahan penyalut yang berbeda. Jurnal Teknologi Hasil Pertanian, 9(1): pp. 1-8. https://doi.org/10.20961/jthp.v9i2.12844.

Rizzo, J., Min, M., Adnan, S., Afzal, N., Maloh, J., Chambers, C.J., Fam, V., and Sivamani, R.K. (2023). Soy protein containing isoflavones improves facial signs of photoaging and skin hydration in postmenopausal women: results of a prospective randomized double-blind controlled trial. Nutrients, 15(19):1-15. https://doi.org/10.3390/nu15194113.

Ravi, D., Usha, G., & Parthasarathy, R. (2013). Microencapsulation technique for selected probiotics and prebiotics. Malaysian Journal of Science, 32(2): pp.33–38. https://doi.org/10.22452/mjs.vol32no1.2.

Shahidi, F., & Han, X.-Q. (1993). Encapsulation of food ingredients. Critical Reviews in Food Science and Nutrition, 33(6): pp.501–547. https://doi.org/10.1080/10408399309527645.

Sucianti, S., Nurhaeni, N., dan Hardi, J. (2020). Mikroenkapsulasi ekstrak kulit buah naga super merah (Hylocereus costaricensis) pada berbagai massa maltodekstrin dan aplikasinya sebagai antioksidan. KOVALEN, 6(3): pp.191-197. https://doi.org/10.22487/kovalen.2020.v6.i3.9889.

Sulistyowati, E., Martono, S., Riyanto, S., Lukitaningsih, E. (2018). Analisis Daidzein dan Genistein pada Kedelai (glycine max l. Merril) Varietas Anjasmoro, Argomulyo dan Dena 2 Menggunakan Metode KCKT. Media Farmasi Indonesia, 13(1): pp.1299–1304. https://mfi.stifar.ac.id/MFI/article/view/40.

Sumardi, Anastasya, D.A., Tarigan, S.T., Insyara, K., dan Yufita, U.M. (2024). Uji aktivitas antioksidan noda klt preparatif dari ekstrak tumbuhan nyirih (Xylocarpus granatum). Forte Journal, 4(1): pp.51-162. https://doi.org/10.51771/fj.v4i1.764.

Supriyadi, dan Rujita, A.S. (2013). Karakteristik mikrokapsul minyak atsiri lengkuas dengan maltodekstrin sebagai enkapsulan. Jurnal Teknologi dan Industri Pangan, 24(2): pp.201-208. https://doi.org/10.6066/jtip.2013.24.2.201.

Syukri, Y. (2018). Teknologi Sediaan Obat dalam Bentuk Solid. Yogyakarta, Universitas Islam Indonesia.

Thomas, N.A., Abdulkadir, W.S., Taupik, M., dan Oktaviana, N. (2021). Pengaruh konsentrasi hydroxypropyl methylcellulose (HPMC) sebagai bahan pengikat pada sediaan tablet ekstrak rimpang jahe merah (Zingiber officinale var. rubrum.). Indonesian Journal of Pharmaceutical Education, 1(3): pp.158-167. https://doi.org/10.37311/ijpe.v1i3.11667.

Tolve, R., Galgano, F., Caruso, M. C., Tchuenbou-Magaia, F. L., Condelli, N., Favati, F., & Zhang, Z. (2016). Encapsulation of health-promoting ingredients: Applications in foodstuffs. International Journal of Food Sciences and Nutrition, 67: pp.1-131. https://doi.org/10.1080/09637486.2016.1205552.

United States Pharmacopeial Convention. (2024). United States Pharmacopeia and National Formulary (USP 43–NF 38), General Chapter <1174> Powder Flow. United States Pharmacopeial Convention.

Wardani, M.A., dan Dewi, L. (2021). Pemanfaatan probiotik dalam cookies labu kuning sebagai strategi pengembangan produk biskuit fungsional. Teknologi Pangan: Media Informasi dan Komunikasi Ilmiah Teknologi Pertanian, 12(2): pp.239-249. https://doi.org/10.35891/tp.v12i2.2574.

Waliansyah, R.R. (2020). Identifikasi Jenis Biji Kedelai (Glycine max L) Menggunakan Gray Level Co-occurrence Matrix (GLCM) dan K-Means Clustering. Jurnal Teknologi Informasi dan Ilmu Komputer, 7(1): pp.17-26. https://doi.org/10.25126/JTIIK202071066.

World Health Organization. (2015)‎. Guideline: Stunting in a nutshell. Available from: https://www.who.int/news/item/19-11-2015-stunting-in-a-nutshell [Accessed January 28, 2024].

Yuliantini, E., Kamsiah, K., dan Maigoda, T.C. (2022). Food intake with stunting events in fisherman family in bengkulu city. Aceh Nutrition Journal, 7(1): pp.79-88. http://dx.doi.org/10.30867/action.v7i1.579.

Zarmpi, P., Flanagan, T., Meehan, E., Mann, J., and Fotaki, N. (2017). Biopharmaceutical aspects and implications of excipient variability in drug product performance. European Journal of Pharmaceutics and Biopharmaceutics, 111(1): pp.1-15. https://doi.org/10.1016/j.ejpb.2016.11.004.

Zegzulka, J., Gelnar, D., Jezerska, L., Prokes, R., and Rozbroj, J. (2020). Characterization and flowability methods for metal powders. Scientific Reports, 10(2): pp.1-19. https://doi.org/10.1007/s40964-023-00484-x.

DOI: https://doi.org/10.20961/jpscr.v10i2.91338

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