Formulasi Tea Tree Oil sebagai Pengawet dalam Masker Gel Peel-Off Ekstrak Etanol Beras Merah (Oryza rufipogon Griff.)

Eka Wulansari, Agus Siswanto, Diniatik Diniatik

Abstract

Bahan pengawet merupakan eksipien yang sangat dibutuhkan dalam sediaan cair seperti masker gel peel-off ekstrak etanol beras merah. Penggunaan paraben diyakini memiliki efek samping jangka panjang pada sistem endokrin dan reproduksi sehingga perlu dikembangkan pengawet alami seperti tea tree oil. Selain faktor kualitas sediaan, faktor harga produk juga seringkali menjadi pertimbangan konsumen dalam membeli produk. Tujuan penelitian ini adalah untuk mendapatkan komposisi optimum bahan pengawet metil paraben, propil paraben, dan tea tree oil dalam sediaan masker gel peel-off ekstrak etanol beras merah. Metode optimasi simplex lattice design (SLD) digunakan untuk optimasi kombinasi pengawet metilparaben, propilparaben, dan tea tree oil dalam 8 run formula. Formula optimum ditentukan dengan parameter pH, daya sebar, waktu mengering, Angka Lempeng Total (ALT), Angka Kapang Khamir (AKK), dan biaya produksi. Hasil penelitian menunjukkan kombinasi tea tree oil, metilparaben, dan propilparaben dapat menjaga stabilitas masker gel peel-off ekstrak etanol beras merah. Berdasarkan optimasi metode numerik diperoleh komposisi optimum pengawet dalam sediaan terdiri dari metilparaben 0,119%, propilparaben 0,151%, dan tea tree oil 0,13%.

Keywords

Preservative; Metilparaben; Propilparaben; Tea tree oil; Masker gel peel-off

References

Abbas, G. A., Irawan, S., Memon, K. . R., Kumar, S., & Elrayah, A. A. I. (2013). Hydroxypropylmethylcellulose As A Primary Viscosifying Agent In Cement Slurry At High Temperature. International Journal Of Automotive And Mechanical Engineering, 8, 1218–1225. Https://Doi.Org/10.15282/Ijame.8.2013.12.0100

Apriani, E. F., Miksusanti, M., & Fransiska, N. (2022). Formulation And Optimization Peel-Off Gel Mask With Polyvinyl Alcohol And Gelatin Based Using Factorial Design From Banana Peel Flour (Musa Paradisiaca L) As Antioxidant. Indonesian Journal Of Pharmacy. Https://Doi.Org/10.22146/Ijp.3408

Apriani, E. F., Nurleni, N., Nugrahani, H. N., & Iskandarsyah, I. (2018). Stability Testing Of Azelaic Acid Cream Based Ethosome. Asian Journal Of Pharmaceutical And Clinical Research, 11(5), 270. Https://Doi.Org/10.22159/Ajpcr.2018.V11i5.23218

Bello, N. S., Antunes, F. T. T., & Martins, M. G. (2022). Essential Oils As Preservatives In Cosmetics: An Integrative Review. Open Access Journal Of Biomedical Science, 4(1). Https://Doi.Org/10.38125/Oajbs.000387

Bupphatanarat, P., Powtongsook, W., Asawahame, C., & Wongtrakul, P. (2020). Application Of Plant Extracts As A Preservative In An Aqueous Gel Formulation. Key Engineering Materials, 859, 172–180. Https://Doi.Org/10.4028/Www.Scientific.Net/Kem.859.172

Butler, H. (Ed.). (2000). Poucher’s Perfumes, Cosmetics And Soaps. Springer Netherlands. Https://Doi.Org/10.1007/978-94-017-2734-1

Dreger, M., & Wielgus, K. (2013). Application Of Essential Oils As Natural Cosmetic Preservatives. Herba Polonica, 59(4), 142–156. Https://Doi.Org/10.2478/Hepo-2013-0030

Dwiputri, A. S., Pratiwi, L., & Nurbaeti, S. N. (2022). Optimasi Formula Sabun Organik Sebagai Scrub Kombinasi Vco, Palm Oil, Dan Olive Oil Menggunakan Metode Simplex Lattice Design [Universitas Tanjungpura]. Http://Etd.Repository.Ugm.Ac.Id/Penelitian/Detail/212281

Fransway, A. F., Fransway, P. J., Belsito, D. V., Warshaw, E. M., Sasseville, D., Fowler, J. F., Dekoven, J. G., Pratt, M. D., Maibach, H. I., Taylor, J. S., Marks, J. G., Mathias, C. G. T., Deleo, V. A., Zirwas, J. M., Zug, K. A., Atwater, A. R., Silverberg, J., & Reeder, M. J. (2019). Parabens. Dermatitis, 30(1), Article 1. Https://Doi.Org/10.1097/Der.0000000000000429

Hanum, S. F., Sihombing, P. N., Ginting, E. E., Shufyani, F., & Naldi, J. (2023). Kombinasi Virgin Coconut Oil (Vco) Dan Ekstrak Etanol Kelopak Jantung Pisang Kepok (Musa Paradisiaca L.) Pada Formulasi Sediaan Pomade. Journal Of Pharmaceutical And Sciences, 6(1), Article 1. Https://Doi.Org/10.36490/Journal-Jps.Com.V6i1.33

Herman, A., Herman, A. P., Domagalska, B. W., & Młynarczyk, A. (2013). Essential Oils And Herbal Extracts As Antimicrobial Agents In Cosmetic Emulsion. Indian Journal Of Microbiology, 53(2), Article 2. Https://Doi.Org/10.1007/S12088-012-0329-0

Huang, J., Yang, L., Zou, Y., Luo, S., Wang, X., Liang, Y., Du, Y., Feng, R., & Wei, Q. (2021). Antibacterial Activity And Mechanism Of Three Isomeric Terpineols Of Cinnamomum Longepaniculatum Leaf Oil. Folia Microbiologica, 66(1), 59–67. Https://Doi.Org/10.1007/S12223-020-00818-0

Huynh, Q., Phan, T. D., Thieu, V. Q. Q., Tran, S. T., & Do, S. H. (2012). Extraction And Refining Of Essential Oil From Australian Tea Tree, Melaleuca Alterfornia, And The Antimicrobial Activity In Cosmetic Products. Journal Of Physics: Conference Series, 352, 012053. Https://Doi.Org/10.1088/1742-6596/352/1/012053

Kairey, L., Agnew, T., Bowles, E. J., Barkla, B. J., Wardle, J., & Lauche, R. (2023). Efficacy And Safety Of Melaleuca Alternifolia (Tea Tree) Oil For Human Health—A Systematic Review Of Randomized Controlled Trials. Frontiers In Pharmacology, 14, 1116077. Https://Doi.Org/10.3389/Fphar.2023.1116077

Kangwan, N., Kongkarnka, S., Pintha, K., Saenjum, C., & Suttajit, M. (2023). Protective Effect Of Red Rice Extract Rich In Proanthocyanidins In A Murine Colitis Model. Biomedicines, 11(2), 265. Https://Doi.Org/10.3390/Biomedicines11020265

Kim, B.-A. (2019). Development Of Cosmetics Preservatives Using Natural Essential Oil. The Journal Of The Convergence On Culture Technology, 5(4), Article 4. Https://Doi.Org/10.17703/Jcct.2019.5.4.445

Kulaksiz Pi̇şki̇n, B., & Seyhan, G. V. (2021). Natural Preservatives. International Journal Of Traditional And Complementary Medicine Research. Https://Doi.Org/10.53811/Ijtcmr.987607

Kunicka-Styczyńska, A., Sikora, M., & Kalemba, D. (2009). Antimicrobial Activity Of Lavender, Tea Tree And Lemon Oils In Cosmetic Preservative Systems: Antimicrobial Action Of Oils In Cosmetics. Journal Of Applied Microbiology, 107(6), Article 6. Https://Doi.Org/10.1111/J.1365-2672.2009.04372.X

Kurnianto, E., Sugihartini, N., & Nurani, L. H. (2017). Hubungan Antara Konsentrasi Minyak Atsiri Kayu Manis (Cinnamomum Burmannii Nees Ex Bl.) Dalam Lotion Dengan Sifat Fisik Dan Tingkat Kesukaan Konsumen. Balaba, 13(1), Article 1. Https://Doi.Org/10.22435/Blb.V13i1. 4813. 21-28

Le, M. T., Nguyen, N. M., & Le, X. T. (2021). Enriching Terpinen-4-Ol From Tea Tree (Melaleuca Alternifolia) Oil Using Vacuum Fractional Distillation: Effect Of Column And Packings On The Separation. Iop Conference Series: Earth And Environmental Science, 947(1), 012001. Https://Doi.Org/10.1088/1755-1315/947/1/012001

Matos, J. D. C., & Cruz, N. R. S. (2018). Atividade Antimicrobiana Do Óleo De Melaleuca Alternifolia Comparada A Conservantes Químicos Usados Em Bases Cosméticas. Revista Remecs - Revista Multidisciplinar De Estudos Científicos Em Saúde, 3(4), 21. Https://Doi.Org/10.24281/Rremecs2526-2874.2018.3.4.21-30

Mitra, P., Chatterjee, S., Paul, N., Ghosh, S., & Das, M. (2021). An Overview Of Endocrine Disrupting Chemical Paraben And Search For An Alternative – A Review. Proceedings Of The Zoological Society, 74(4), Article 4. Https://Doi.Org/10.1007/S12595-021-00418-X

Mulya Lestari, P., Sutyasningsih, & Fadila, M. (2015). Carbomer 980 Dalam Masker Gel Peel–Off Sari Buah Nanas (Ananas Comosus L. Merr). Farmasains, 2(6), 264–268.

National Center For Biotechnology Information. (2023). Pubchem Compound Summary For Cid 1030, Propylene Glycol. National Center For Biotechnology Information. Https://Pubchem.Ncbi.Nlm.Nih.Gov/Compound/Propylene-Glycol

Ningsih, A. W., Nurrosyidah, I. H., Stikes Rumah Sakit Anwar Medika, Departemen Biologi Farmasi, Stikes Rumah Sakit Anwar Medika, Hisbiyah, A., & Stikes Rumah Sakit Anwar Medika. (2018). Pengaruh Perbedaan Metode Ekstraksi Rimpang Kunyit (Curcuma Domestica) Terhadap Rendemen Dan Skrining Fitokimia. Journal Of Pharmaceutical-Care Anwar Medika, 2(2), 49–57. Https://Doi.Org/10.36932/Jpcam.V2i2.27

Nogueira, M. N. M., Aquino, S. G., Rossa Junior, C., & Spolidorio, D. M. P. (2014). Terpinen-4-Ol And Alpha-Terpineol (Tea Tree Oil Components) Inhibit The Production Of Il-1β, Il-6 And Il-10 On Human Macrophages. Inflammation Research, 63(9), 769–778. Https://Doi.Org/10.1007/S00011-014-0749-X

Partuti, T., Priyanti, P., Nadyana, H. E., & Daniya, A. A. (2021). Characteristics Of Mangosteen Rind Peel Off Gel Mask With Various Concentrations. Teknika: Jurnal Sains Dan Teknologi, 17(1), Article 1. Https://Doi.Org/10.36055/Tjst.V17i1.10401

Patterson, J. E., Mcelmeel, L., & Wiederhold, N. P. (2019). In Vitro Activity Of Essential Oils Against Gram-Positive And Gram-Negative Clinical Isolates, Including Carbapenem-Resistant Enterobacteriaceae. Open Forum Infectious Diseases, 6(12), Article 12. Https://Doi.Org/10.1093/Ofid/Ofz502

Peraturan Badan Pengawas Obat Dan Makanan Tentang Persyaratan Teknis Bahan Kosmetika, Pub. L. No. 23 (2019).

Poudel, A., Dosoky, N. S., Satyal, P., Swor, K., & Setzer, W. N. (2023). Essential Oil Composition Of Grindelia Squarrosa From Southern Idaho. Molecules, 28(9), 3854. Https://Doi.Org/10.3390/Molecules28093854

Rathee, P., Sehrawat, R., Rathee, P., Khatkar, A., Akkol, E. K., Khatkar, S., Redhu, N., Türkcanoğlu, G., & Sobarzo-Sánchez, E. (2023). Polyphenols: Natural Preservatives With Promising Applications In Food, Cosmetics And Pharma Industries; Problems And Toxicity Associated With Synthetic Preservatives; Impact Of Misleading Advertisements; Recent Trends In Preservation And Legislation. Materials, 16(13), 4793. Https://Doi.Org/10.3390/Ma16134793

Rejeki, S., Sukmajati, F., & Ningsih-Politeknik Kesehatan Bhakti Mulia, S. (2021). Ekstraksi Dan Penetapan Nilai Spf Ekstrak Etanol Beras Hitam (Oryza Sativa L Indica) Secara In Vitro Dengan Metode Spektrofotometri. Indonesian Journal On Medical Science, 8(1), Article 1. Https://Doi.Org/10.55181/Ijms.V8i1.260

Sarkic, A., dan Stappen, I. (2018). Essential Oils And Their Single Compounds In Cosmetics—A Critical Review. Cosmetics, 5(1), 11. Https://Doi.Org/10.3390/Cosmetics5010011

Saryanti, D., Setiawan, I., & Safitri, R. A. (2019). Optimasi Formula Sediaan Krim M/A Dari Ekstrak. 1(3). Dari Ekstrak Kulit Pisang Kepok (Musa Acuminata L.). Jurnal Riset Kefarmasian Indonesia, 1(3), 225–237

Sriram, S., Singh, R. K., & Kumar, A. (2020). Oil-Water Separation Through An Ultrahydrophobic Filter Paper Developed By Sol-Gel Dip-Coating Technique. Materials Today: Proceedings, 26, 2495–2501. Https://Doi.Org/10.1016/J.Matpr.2020.02.531

Stat-Ease, Inc. (2023). Stat-Ease. Stat-Ease. Diakses Pada 4 Mei 2023. Https://Www.Statease.Com/Docs/V11/Contents/Optimization/Desirability-Function/

Sutarna, T. H., Ngadeni, A., & Anggiani, R. (2013). Formulasi Sediaan Masker Gel Dari Ekstrak Etanol Daun Teh Hijau (Camellia Sinensis L.) Dan Madu Hitam (Apisdorsata) Sebagai Antioksidan. Kartika Jurnal Ilmiah Farmasi, 1(1), 23. Https://Doi.Org/10.26874/Kjif.V1i1.23

Tanjung, Y. P., & Rokaeti, A. M. (2020). Formulasi Dan Evaluasi Fisik Masker Wajah Gel Peel Off Ekstrak Kulit Buah Naga Merah (Hylocereus Polyrhizus). Majalah Farmasetika., 4. Https://Doi.Org/10.24198/Mfarmasetika.V4i0.25875

Voight, R. (1995). Buku Pelajaran Teknologi Farmasi Terjemahan (5th Ed.). Gadjah Mada University Press.

DOI: https://doi.org/10.20961/jpscr.v9i1.78349

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