Systematic Review: Skrining Aktivitas Anti Quorum sensing Tumbuhan Terhadap Pseudomonas aeruginosa

Estu Retnaningtyas Nugraheni, Anindita Aulianisa W, Artini Pangastuti

Abstract

Multi Drug Resistance (MDR) yang ditunjukkan Pseudomonas aeruginosa salah satunya dilatar belakangi oleh faktor virulensi seperti Las A, Las B dan formasi biofilm. Proses produksi ini dikontrol oleh sistem komunikasi quorum sensing (QS), sehingga penghambatan QS berpotensi mencegah resistansi lebih lanjut. Fitokomponen telah dilaporkan memiliki aktivitas anti QS, tetapi belum terdapat review yang merangkum laporan tersebut secara sistematis dan komprehensif. Penelitian ini bertujuan mengidentifikasi dan menyediakan rujukan berkualitas tentang aktivitas anti QS tumbuhan terhadap P. aeruginosa yang memenuhi parameter tertentu dalam bentuk Systematic Review. Systematic Review ini mengikuti permodelan PRISMA, analisis data menggunakan meta-sintesis-meta-agregasi, dan pencarian paper di 3 database (Pubmed, Sciencedirect, Scopus) menggunakan kata kunci Pseudomonas aeruginosa AND Quorum sensing AND Plants. Paper berjumlah 26 paper lolos saring yang memuat informasi terkait 18 famili (25 genus dan 28 spesies), 11 jenis organ tumbuhan, 3 jenis metode purifikasi, 4 jenis aktivitas anti QS dan 21 jenis fitokomponen yang dilaporkan menunjukkan aktivitas anti QS terhadap bakteri C. violaceum dan P. aeruginosa. Data yang tersedia dari 26 paper menunjukkan 9 laporan menyajikan data aktivitas anti QS relatif tinggi. Laporan tersebut terbagi menjadi 3 tingkat metode purifikasi yaitu isolat petroleum eter-etil asetat yang menghasilkan fitokomponen golongan phytosterol, fraksi etil asetat yang menghasilkan fitokomponen golongan flavonoid, dan ekstrak dengan pelarut metanol yang menghasilkan fitokomponen golongan terpenoid dan turunannya.

Keywords

Pseudomonas aeruginosa; quorum sensing; resistansi; tumbuhan

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References

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DOI: https://doi.org/10.20961/jpscr.v8i1.64578

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