Narrative Review: Herbal Nanocosmetics for Anti Aging

Prilyano Garcella, Triyadi Hendra Wijaya, Dhadhang Wahyu Kurniawan

Abstract

Skin aging is a complex biological process caused by intrinsic and extrinsic factors. There are various approaches to preventing skin aging, one of which is using herbal nanocosmetics. This narrative review aims to determine the natural ingredients, type of nanoformulations, and its effects of herbal nanocosmetics to prevent skin aging. The method used in this study was searching for articles related to herbal nanocosmetics to avoid aging skin through Google Scholar, PubMed, and Science Direct with the keywords herbal plants, anti-aging, herbal cosmetics, cosmetics, nanocosmetics, nanoformulations, nanoparticles, nanomaterials, and topical delivery. The inclusion criteria were research articles or review articles about herbal plants made into herbal nanocosmetics to prevent skin aging with the topical route of administration published between 2010-2021 in full text. The articles that have been obtained are then selected, reviewed, and analyzed. Herbal plants made into herbal nanocosmetics contain phenolic compounds for nanoformulations used, namely silver nanoparticles, solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), nanoemulsions, liposomes, niosomes, ethosomes, and transfersomes. These nanocosmetics herbs affect skin aging, including UV protection, preventing wrinkles and dark spots, moisturizing and brightening the skin. The herbal nanocosmetics prevent the effects of skin aging through some mechanisms such as anti-oxidant, photoprotective agents, modulators of collagen or elastin synthesis, and inhibitors of melanin synthesis.

Keywords

Anti aging; cosmetics; herbal nanocosmetics; herbal plants; nanotechnology

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References

Ahmed, I. A., Mikail, M. A., Zamakshshari, N., and Abdullah, A. S. H. (2020). Natural Anti-Aging Skincare: Role and Potential. Biogerontology, 21(3), 293–310. https://doi.org/10.1007/s10522-020-09865-z

Amer, R. I., Ezzat, S. M., Aborehab, N. M., Ragab, M. F., Mohamed, D., Hashad, A., Attia, D., Salama, M. M., and El Bishbishy, M. H. (2021). Downregulation of MMP1 Expression Mediates the Anti-Aging Activity of Citrus sinensis Peel Extract Nanoformulation in UV Induced Photoaging in Mice. Biomedicine and Pharmacotherapy, 123, 111537. https://doi.org/10.1016/j.biopha.2021.111537

Aziz, Z. A. A., Mohd-Nasir, H., Ahmad, A., Siti, S. H., Peng, W. L., Chuo, S. C., Khatoon, A., Umar, K., Yaqoob, A. A., and Mohamad Ibrahim, M. N. (2019). Role of Nanotechnology for Design and Development of Cosmeceutical: Application in Makeup and Skin Care. Frontiers in Chemistry, 7, 739. https://doi.org/10.3389/fchem.2019.00739

Baitariza, A., Darijanto, S. T., Pamudji, J. S., and Fidrianny, I. (2014). Formulasi dan Evaluasi Mikroemulsi Antikerut Ekstrak Beras Hitam (Oryza sativa L.). Indonesian Journal of Pharmaceutical Science and Technology, 1(1), 18.

Balestrin, L. A., Bidone, J., Bortolin, R. C., Moresco, K., Moreira, J. C., and Teixeira, H. F. (2016). Protective Effect of a Hydrogel Containing Achyrocline satureioides Extract-loaded Nanoemulsion Against UV-Induced Skin Damage. Journal of Photochemistry and Photobiology B: Biology, 163, 269–276. https://doi.org/10.1016/j.jphotobiol.2016.08.039

Baumann, L. (2018). How to Use Oral and Topical Cosmeceuticals to Prevent and Treat Skin Aging. Facial Plastic Surgery Clinics of North America, 26(4), 407–413. https://doi.org/10.1016/j.fsc.2018.06.002

Campa, M., and Baron, E. (2018). Anti-Aging Effects of Select Botanicals: Scientific Evidence and Current Trends. Cosmetics, 5(3), 54. https://doi.org/10.3390/COSMETICS5030054

Chaiyana, W., Anuchapreeda, S., Punyoyai, C., Neimkhum, W., Lee, K. H., Lin, W. C., Lue, S. C., Viernstein, H., and Mueller, M. (2019). Ocimum sanctum Linn. as a Natural Source of Skin Anti-Ageing Compounds. Industrial Crops and Products, 127, 217–224. https://doi.org/10.1016/j.indcrop.2018.10.081

de Lima Cherubim, D. J., Buzanello Martins, C. V., Oliveira Fariña, L., and da Silva de Lucca, R. A. (2020). Polyphenols as Natural Anti-Oxidants in Cosmetics Applications. Journal of Cosmetic Dermatology, 19(1), 33–37. https://doi.org/10.1111/jocd.13093

Desmiaty, Y., Saputri, F. C., Hanafi, M., Prastiwi, R., and Elya, B. (2020). Anti-Elastase, Anti-Tyrosinase, and Anti-Oxidant of Rubus fraxinifolius Stem Methanolic Extract. Pharmacognosy Journal, 12(2), 271–275.

Garcês, A., Amaral, M. H., Sousa Lobo, J. M., and Silva, A. C. (2018). Formulations Based on Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC) for Cutaneous Use: A review. European Journal of Pharmaceutical Sciences, 112, 159–167. https://doi.org/10.1016/j.ejps.2017.11.023

Hwang, I. S., Kim, J. E., Choi, S. Il, Lee, H. R., Lee, Y. J., Jang, M. J., Son, H. J., Lee, H. S., Oh, C. H., Kim, B. H., Lee, S. H., and Hwang, D. Y. (2012). UV Radiation-Induced Skin Aging in Hairless Mice is Effectively Prevented by Oral Intake of Sea Buckthorn (Hippophae rhamnoides L.) Fruit Blend for 6 Weeks through MMP Suppression and Increase of SOD Activity. International Journal of Molecular Medicine, 30(2), 392–400. https://doi.org/10.3892/ijmm.2012.1011

Isaac, V., Chiari, B. G., Miglioli, K., Moreira, R., Oliveira, J. R. S., Salgado, H., Relkin, P., Corrêa, M. A., Salgado, A., and Ribeiro, H. M. (2012). Development of a Topical Formulation Containing S. lutea Extract: Stability, In Vitro Studies and Cutaneous Permeation. Journal of Applied Pharmaceutical Science, 2(8), 174–179. https://doi.org/10.7324/JAPS.2012.2830

Jadoon, S., Karim, S., Asad, M. H. H. Bin, Akram, M. R., Kalsoom Khan, A., Malik, A., Chen, C., and Murtaza, G. (2015). Anti-Aging Potential of Phytoextract Loaded-Pharmaceutical Creams for Human Skin Cell Longetivity. Oxidative Medicine and Cellular Longevity, 1–17. https://doi.org/10.1155/2015/709628

Kasote, D. M., Katyare, S. S., Hegde, M. V., and Bae, H. (2015). Significance of Anti-Oxidant Potential of Plants and its Relevance to Therapeutic Applications. International Journal of Biological Sciences, 11(8), 982–991. https://doi.org/10.7150/ijbs.12096

Kaur, C. D., and Saraf, S. (2011). Topical Vesicular Formulations of Curcuma longa Extract on Recuperating the Ultraviolet Radiation-Damaged Skin. Journal of Cosmetic Dermatology, 10(4), 260–265. https://doi.org/10.1111/j.1473-2165.2011.00586.x

Kemenkes RI. (2019). Profil Kesehatan Indonesia Tahun 2018. Jakarta: Kementerian Kesehatan Republik Indonesia.

Khare, R., Upmanyu, N., and Jha, M. (2019). Exploring the Potential Effect of Methanolic Extract of Salvia officinalis Against UV Exposed Skin Aging: In vivo and In vitro Model. Current Aging Science, 14(1), 46–55.

Khezri, K., Saeedi, M., and Maleki Dizaj, S. (2018). Application of Nanoparticles in Percutaneous Delivery of Active Ingredients in Cosmetic Preparations. Biomedicine and Pharmacotherapy, 106, 1499–1505. https://doi.org/10.1016/j.biopha.2018.07.084

Kusumawati, I., Kurniawan, K. O., Rullyansyah, S., Prijo, T. A., Widyowati, R., Ekowati, J., Hestianah, E. P., Maat, S., and Matsunami, K. (2018). Anti-Aging Properties of Curcuma heyneana Valeton & Zipj: A scientific Approach to its Use in Javanese Tradition. Journal of Ethnopharmacology, 225, 64–70. https://doi.org/10.1016/j.jep.2018.06.038

Leelapornpisid, P., Kiattisin, K., Jantrawut, P., and Phrutivorapongkul, A. (2014). Nanoemulsion Loaded With Marigold Flower Extract (Tagetes erecta Linn) In Gel Preparation As Anti-Wrinkles Cosmeceutical. International Journal of Pharmacy and Pharmaceutical Sciences, 6(2), 231-236.

Limtrakul, P., Yodkeeree, S., Thippraphan, P., Punfa, W., and Srisomboon, J. (2016). Anti-Aging and Tyrosinase Inhibition Effects of Cassia fistula Flower Butanolic Extract. BMC Complementary and Alternative Medicine, 16(1), 1–9. https://doi.org/10.1186/s12906-016-1484-3

Lin, R. F., Feng, X. X., Li, C. W., Zhang, X. J., Yu, X. T., Zhou, J. Y., Zhang, X., Xie, Y. L., Su, Z. R., and Zhan, J. Y. X. (2014). Prevention of UV Radiation-Induced Cutaneous Photoaging in Mice by Topical Administration of Patchouli Oil. Journal of Ethnopharmacology, 154(2), 408–418. https://doi.org/10.1016/j.jep.2014.04.020

Lister, I. N. E., Amiruddin, H. L., Fachrial, E., and Girsang, E. (2021). Anti-Aging Effectiveness of Avocado Peel Extract Ointment (Persea americana Mill.) Against Hydration, Collagen, and Elasticity Levels in Wistar Rat. Journal of Pharmaceutical Research International, 173–184. https://doi.org/10.9734/jpri/2021/v33i32b31760

Mahdi, E. S., Noor, A. M., Sakeena, M. H., Abdullah, G. Z., Abdulkarim, M. F., and Sattar, M. A. (2011). Formulation and In Vitro Release Evaluation of Newly Synthesized Palm Kernel Oil Esters-Based Nanoemulsion Delivery System for 30% Ethanolic Dried Extract Derived from Local Phyllanthus Urinaria for Skin Anti-Aging. International Journal of Nanomedicine, 2499–2512. https://doi.org/10.2147/ijn.s22337

Maity, N., Nema, N. K., Abedy, M. K., Sarkar, B. K., and Mukherjee, P. K. (2011). Exploring Tagetes erecta Linn Flower for the Elastase, Hyaluronidase and MMP-1 Inhibitory Activity. Journal of Ethnopharmacology, 137(3), 1300–1305. https://doi.org/10.1016/j.jep.2011.07.064

Manosroi, A., Chutoprapat, R., Abe, M., Manosroi, W., and Manosroi, J. (2012). Anti-Aging Efficacy of Topical Formulations Containing Niosomes Entrapped with Rice Bran Bioactive Compounds. Pharmaceutical Biology, 50(2), 208–224. https://doi.org/10.3109/13880209.2011.596206

Manosroi, J., Chankhampan, C., Kitdamrongtham, W., Zhang, J., Abe, M., Akihisa, T., Manosroi, W., and Manosroi, A. (2020). In Vivo Anti-Ageing Activity of Cream Containing Niosomes Loaded with Purple Glutinous Rice (Oryza sativa Linn.) Extract. International Journal of Cosmetic Science, 42(6), 622–631. https://doi.org/10.1111/ics.12658

Mostafa, E., Fayed, M. A. A., Radwan, R. A., and Bakr, R. O. (2019). Centaurea pumilio L. Extract and Nanoparticles: A Candidate for Healthy Skin. Colloids and Surfaces B: Biointerfaces, 182, 110350. https://doi.org/10.1016/j.colsurfb.2019.110350

Mostafa, E. S., Maher, A., Mostafa, D. A., Gad, S. S., Nawwar, M. A. M., and Swilam, N. (2021). A Unique Acylated Flavonol Glycoside from Prunus persica (L.) var. florida Prince: A New Solid Lipid Nanoparticle Cosmeceutical Formulation for skincare. Antioxidants, 10(3), 436. https://doi.org/10.3390/antiox10030436

Muhammad, A., Akhtar, N., and Hameed, A. (2019). Phytochemical Profiling of Avena sativa for Phytoantioxidants Compounds with their Multidirectional Non-Invasive Investigation for Anti-Pigmenting and Facial Skin Fatiguing Effect with a stable Emulgel Formulation. Biomedical Research, 30(3), 456–464.

Noor, S. U., Laksmitawati, D. R., and Sumaryono, W. (2020). In-Vitro Antihyaluronidase Activity and Physical Properties of Alpinia zerumbet Rhizome Extract-Loaded Nanostructured Lipid Carrier. Jurnal Ilmu Kefarmasian Indonesia, 18(1), 48–52.

Otlatici, G., Yegen, G., Gungor, S., and Aksu, B. (2019). Overview on Nanotechnology Based Cosmeceuticals to Prevent Skin Aging. Istanbul Journal of Pharmacy, 48(2), 55–62. https://doi.org/10.5152/istanbuljpharm.2018.424278

Pientaweeratch, S., Panapisal, V., and Tansirikongkol, A. (2016). Antioxidant, Anti-collagenase and Anti-elastase Activities of Phyllanthus emblica, Manilkara zapota and silymarin: an in Vitro Comparative Study for Anti-aging Applications. Pharmaceutical Biology, 54(9), 1865–1872. https://doi.org/10.3109/13880209.2015.1133658

Radwan, R. A., El-Sherif, Y. A., and Salama, M. M. (2020). A Novel Biochemical Study of Anti-Ageing Potential of Eucalyptus camaldulensis Bark Waste Standardized Extract and Silver Nanoparticles. Colloids and Surfaces B: Biointerfaces, 191, 111004. https://doi.org/10.1016/j.colsurfb.2020.111004

Rahman, H. S., Othman, H. H., Hammadi, N. I., Yeap, S. K., Amin, K. M., Samad, N. A., and Alitheen, N. B. (2020). Novel Drug Delivery Systems for Loading of Natural Plant Extracts and their Biomedical Applications. International Journal of Nanomedicine, 2439–2483. https://doi.org/10.2147/IJN.S227805

Rameshk, M., Sharififar, F., Mehrabani, M., Pardakhty, A., Farsinejad, A., and Mehrabani, M. (2018). Proliferation and In Vitro Wound Healing Effects of the Microniosomes Containing Narcissus tazetta L. Bulb Extract on Primary Human Fibroblasts (HDFs). Journal of Pharmaceutical Sciences, 26(1), 31–42. https://doi.org/10.1007/s40199-018-0211-7

Salem, M. A., Radwan, R. A., Mostafa, E. S., Alseekh, S., Fernie, A. R., and Ezzat, S. M. (2020). Using an UPLC/MS-based Untargeted Metabolomics Approach for Assessing the Antioxidant Capacity and Antiaging Potential of Selected Herbs. RSC Advances, 10(52), 31511–31524. https://doi.org/10.1039/d0ra06047j

Shanbhag, S., Nayak, A., Narayan, R., and Nayak, Yogendra, U. (2019). Anti-aging and Sunscreens: Paradigm Shift in Cosmetics. Advanced Pharmaceutical Bulletin, 9(3), 348.

Souto, E. B., Fernandes, A. R., Martins-Gomes, C., Coutinho, T. E., Durazzo, A., Lucarini, M., Souto, S. B., Silva, A. M., and Santini, A. (2020). Nanomaterials for Skin Delivery of Cosmeceuticals and Pharmaceuticals. Applied Sciences (Switzerland), 10(5). https://doi.org/10.3390/app10051594

Warsito, M. F., and Kusumawati, I. (2019). The Impact of Herbal Products in the Prevention, Regeneration and Delay of Skin Aging. Reviews on Biomarker Studies in Aging and Anti-Aging Research, 155-174. https://doi.org/10.1007/978-3-030-25650-0_9

Zofia, N. Ł., Martyna, Z. D., Aleksandra, Z., and Tomasz, B. (2020). Comparison of the Anti-aging and Protective Properties of Plants from the Apiaceae Family. Oxidative Medicine and Cellular Longevity, 2020. https://doi.org/10.1155/2020/5307614

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