Pengkajian Terapi COVID-19 Pada Pasien Rawat Inap Komorbid Hipertensi Terhadap Derajat Keparahan Penyakit di RSJPD Harapan Kita

Adin Hakim Kurniawan, Nanda Puspita, Tri Indriyani Meitinawati, Lestiani Lestiani

Abstract

Kematian akibat Covid-19 menurut Centers for Disease Control and Prevention di Amerika Serikat terjadi pada pasien rentan dan memiliki riwayat komorbid penyakit seperti hipertensi. Virus SARS Cov-19 masuk kedalam sel manusia dan menginfeksi melalui ikatan dengan reseptor Angitensin Converting Enzym 2 (ACE 2). Terapi farmakologi pada penanganan Covid-19 dengan riwayat komorbid hipertensi dalam tahap pengujian secara klinis masih perlu dilakukan monitoring pengobatan yang tepat dan rasional sehingga perlu pengkajian farmakoterapi berdasarkan derajat keparahan penyakit. Penelitian ini bertujuan memahami faktor yang mempengaruhi derajat keparahan penyakit dan karakteristik terapi Covid-19 pada pasien rawat inap komorbid hipertensi. Penelitian ini menggunakan desain penelitian cohort retrospective. Pengambilan data di RSJPD Harapan menggunakan rekam medis pasien rawat inap dengan pasien Covid-19  pada komorbid hipertensi pada periode November 2020 sampai April 2021. Teknik pengambilan sampel menggunakan consequtive sampling dan Analisis statistik Chi square. Hasil penelitian menunjukan,dari 80 pasien, subjek penelitian laki-laki sebanyak 45 pasien (56,31%), usia produktif 45 pasien (56,30%). Kesesuaian peresepan dosis dan frekuensi terapi Covid-19sebesar 99,03%. Hasil analisis bivariat menunjukan adanya perbedaan bermakna pada pemberian terapi suportif Covid-19 (p=0,034), saturasi oksigen (p=0,024) serta lama perawatan pasien (p=0,008) terhadap derajat keparahan penyakit. Adapun hasil terapi Covid-19 memiliki perbedaan bermakna terhadap derajat keparahan, terdapat pada terapi levofloxacin (p=0,034);osetalmivir (p=0,030); favipiravir (p=0,027); remdesivir (p=0,009) dan spironolakton (p=0,034).

Keywords

derajat keparahan; komorbid hipertensi; terapi Covid-19

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