Cytotoxic Activity Of Non Polar Fraction From Annona Muricata L. Leaves On Hela And Raji Cell Line

Anif Nur Artanti, Okid Parama Astirin, Adi Prayitno

Abstract

The main focus of the research is cancer by a viral infection such as nasopharinx and cervical cancer that have high incidence in Indonesia. Cervical cancer is due to the viral infection known as the Human Papilloma Virus (HPV) and nasopharing cancer is a cancer that is caused by EBV infection (Eppstein Barr virus). The main priority of nasopharinx  and servix cancer treatment is the use of chemotherapeutic agents, but it might also lead to diverse side-effects. The focus of this study was to develop the potency of non polar fraction from Annona muricata L. leaves by observing the cytotoxic effect on Hela and Raji cancer cell line.

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References

C. C. Liaw, F.-R. Chang, C.-Y. Lin, C.-J. Chou, H.-F. Chiu, M.-J. Wu and Y.-C. Wu, “New Cytotoxic Mono- tetrahydrofuran Annonaceous Acetogenins from Annona muricata,” Journal of Natural Products, Vol. 65, No. 4, 2002, pp. 470-475.

Chen, J.C, Hsu, W.L, Yang, H.I, Lee, M.H, Chen, H.C, Chien, Y.C, and You, S.L, 2014, Epidemiology of Virus Infection and Human Cancer, Cancer Research : 193.

Forman, D., Catherine de Martel, Lacey, C.J., Soerjomataram, I., Lortet-Tieulent, J., Bruni, L., Vignat, J., Ferlay, J., Bray, F., Plummer, M., Franceschi, S. 2012. Global Burden of Human Papillomavirus and Related Diseases. Vaccine 30S: F12– F23.

IARC. 2009.International Agency for Research on Cancer A review of human carcinogens. Part B: biological agent. IARC, Lyon, IARC.

Leaver, D. and Labonte, G. 2010. HPV and Cervical Cancer. Radiation 19, 27-44.

Lee, Young-Man, Jeong, Gil-Saeng, Lim, Hyun-Dae, An, Ren-Bo, Kim, YounChul, and Kim, Eun-Cheol, 2010. “Isoliquiritigenin 2’-methyl ether induces growth inhibition and apoptosis in oral cancer cells via heme oxygenase-1.

Miller, R.P., Tadagavadi, R.K., Ramesh, G., and Reeves, W.B. 2010. Mechanisms of Cisplatin Nephrotoxicity. Toxins 2: 2490-2518.

Mukherjea, D. and Rybak, L.P. 2011. Pharmacogenomics of cisplatin-induced ototoxicity. Pharmacogenomics 12(7): 1039–1050.

Newman, D.J, dan Cragg, G.M, 2007, Natural Products as Sources of New Drugs Over The Last 25 Years, J. Nat. Prod, 70: 461-477.

Prayong, P., Barusrux, S., and Weerapreeyakul, N., 2008, Cytotoxic activity screening of some indigenous Thai plants", Fitoterapia, 79(7-8), hal. 598- 601.

Rabik, C.A., and Dolan, M.E. 2007. Molecular mechanisms of resistance and toxicity associated with platinating agents. Cancer Treatment Reviews, 33: 9– 23.

Sirichanchuen, B., Pengsuparp, T., and Chanvorachote, P. 2012. Long-term cisplatin exposure impairs autophagy and causes cisplatin resistance in human lung cancer cells. Mol Cell Biochem 364:11–18.

DOI: https://doi.org/10.20961/jpscr.v1i2.1944

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