Anti-inflammatory Effect of cream and ointment from 2,5- bis- (4-Nitrobenzilidine) cyclopentanoneagainst Edema in Mice Induced by Formalin

Paulina Maya Octasari, Fransiska Ayuningtyas

Abstract

Creams and ointments are topical dosage forms used in the manufacture of drugs. Topical anti-inflammatory drug is a solution to problems of gastrointestinal side effects caused by taking nonsteroidal anti-inflammatory drug orally. The compound 2,5-bis (4-nitrobenzilidine) cyclopentanone is an analog of curcumin which has better anti-inflammatory activity than curcumin. This study aimed to determine the antiinflammatory effect of cream and ointment from 2,5-bis (4-nitrobenzilidine) cyclopentanoneagainst edema in mice induced by formalin. This research were experimental randomized complete design using a single factor. Twenty mice were divided into 4 groups: group I were given a cream base, the group II were given ointment base, group III were given cream compound 0.25% and group IV were given ointment compound 0.25%. The data were processed into AUC values and the percentage of anti-inflammatory effectwere calculated. Results were analyzed using ANOVA and T-test statistics. The results showed that between the dosage form had statistically difference of anti-inflammatory effect (p<0.05). The ointmentshowed a greater value of antiinflammatory activity rather than cream.

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References

Anand, Sundaram, Jhurani, Kunnumakkara dan Anggarwal. 2008. Curcumin and Cancer: An Old-Age Disease with an Age-Old Solution. Cancer Letter. 1 (267) : 133-164.

Ansel, H.C., 1989. Pengantar Bentuk Sediaan Farmasi Edisi IV. Jakarta: Universitas Indonesia Press.

Araujo, dan Leon. 2001. Biological Activities of Curcuma longa L. MemInst Oswaldo Cruz, Rio de Janeiro. 96 (5): 723-728.

Afshariani, R., Farhadi, P., Ghaffarpasand, F., and Roozbeh, J., 2014., Effectiveness of Topical Curcumin for Treatment of Mastitis in Breastfeeding Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, Oman Medical Journal, Vol. 29, No. 5:330-334.

Budiarti, T., Suzana, dan Surdijati, S., 2010. Sintesis, Uji Aktivitas Analgesik dan Antiinflamasi Senyawa Benzoiltiourea Tersubstitusi. Majalah Farmasi Indonesia, 21 (2), 68-76.

Cannon, K.E., Leurs R., and Hough L.B., 2007. Activation of Peripheral and Spinal Histamine H3 Receptors Inhibits Formalin-Induced Inflammation and Nociception, Respetively. Pharmacol Biochem Behav., 88 (1), 122-129.

Chainani-Wu, N., 2003. Safety and Anti-inflamatory Activity of Curcumin: A Component of Tumeric (Curcuma Longa). The Journal of Alternative and Complementary Medicine, 9 (1), 161-168.

Gunani, S. B., 2009, Uji Daya Antiinflamasi Krim Tipe A/M Ekstrak Etanolik Jahe 10% (Zingiberofficinale Roscoe) yang Diberikan Topikal Terhadap Udem Kaki Tikus yang Diinduksi Karagenin, LaporanPenelitian, Surakarta.

Itokawa, H., Shi, Q., Akiyama, T., Morris-Natschke, S.L., & Lee, K.H., 2008. Review: Recent Advances In The Investigation Of Curcuminoids. BioMed Central [online]. Dapat dilihat pada: http://www.cmjournal.org/ [diakses pada 1 Mei 2016].

Jayaprakasha, G, K., Jagan Mohan Rao dan Sakariah, K, K., 2006. Antioxidant Activities of Curcumin, Demethoxycurcumin and Bisdemethoxycurcumin. Food Chemistry. 98, 720-724.

Katzung, G.B., 2002. Farmakologi Dasar dan Klinik, Edisi 8. Jakarta: Salemba Medika.

Kee. J. L. and Hayes. E. R, 1996, FarmakologiPendekatan Proses Keperawatan, edisi 5, diterjemahkan Peter. A., 310-317, BukuKedokteran EGC, Jakarta.

Lopez-Jornet P, Camacho-Alonso F, Jimenez-Torres MJ, Orduna-Domingo A, Gomez-Garcia F. 2011. Topical curcumin for the healing of carbon dioxide laser skin wounds in mice. Photomed Laser Surg. 29:809-14.

Majeed, M., Badmaev, V., Shivakumar, U., and Rajendran, R., 1995. Curcuminoids Antioxidant Phytonutrients. United States Of America: Nutriscience Publisher Piscataway.

Niazi, P.P., Vikas, G., and Narinderpal K., 2010.

Pharmacotherapeutics Of Curcuma Longa-A Potent Patent, International Journal Of Pharma Professional’s Research. 1: 24-30.

Nurrochmad, A., 1997, Penghambatan Biosintesis Prostaglandin Melalui Jalur Siklooksigenase oleh Siklovalon dan Tiga Senyawa Analognya, Skripsi, Fakultas Farmasi Universitas Gadjah Mada, Yogyakarta

Octasari, P.M., dan Djunarko, I., 2012. Efek Anti-Inflamasi Benzoil Eugenol secara Topikal terhadap Edema Kaki yang Diinduksi Formalin 0,5% pada Mencit Jantan Galur Swiss. Jurnal Farmasi Sains dan Komunitas, 9 (1), 26-35.

Pandey, and Sanjay, K., 2010. Determination and Comparison of The Curcuminoid Pigments in Tumeric Genotypes (Curcuma Domestica Val) by Highperformance Liquid Chromatography, International Journal of Pharmacy and Pharmaceutical Sciences. 2 (4): 125-127.

Rhen, T. dan Cidlowski J.A., 2005. Antiinflammatory action of glucocorticoids-new mechanisms for old drugs. N Engl J Med, No. 353. Dapat dilihat pada: http://www.nejm.org/ [Diakses pada 20 Desember 2014].

Robinson, T., Ehlers, R.B., Hubbard, X., Bai, J.L., Arbiser, D.J., Goldsmith, J.p., Bowen. 2003. Design, Synthesis and Biological Evaluation Of Aromatic Enones, Related to Curcumin, Bioorg. Med. Chem. Let.13, 115-117.

Sopiyudin, M.D., 2014. Statistik Untuk Kedokteran Dan Kesehatan, Seri 1 edisi 6. Jakarta: Epidemiologi Indonesia

Sun J, Zhao Y, Hu J. 2013. Curcumin inhibits imiquimod-induced psoriasis-like inflammation by inhibiting IL-1beta and IL-6 production in mice. PLoS One. 8:e67078.

Tonnesen, H. H. dan Karlsen, J., 1985. Studies of Curcumin and Curcuminoids: VI. Kinetics of Curcumin Degradation in Aqueous Solutions. Z. Lebensm.Unters. Forsch, 180(5), 402-4. Dapat dilihat pada: http://www.ncbi.nlm.nih.gov/ [Diakses pada 20 Desember 2014].

Tonnesen, H. H., Karlsen, J., dan Van Henegouwen G.B., 1986. Studies of Curcumin and Curcuminoids: VIII. Photochemical stability of Curcumin. Z. Lebensm.Unters. Forsch, 183(2), 116-22. Dapat dilihat pada: http://www.ncbi.nlm.nih.gov/ [Diakses pada 20 Desember 2014].

Widyastani, F.A. dan Hariono, M., 2013. Synthesis of 2,5-bis-(4-nitrobenzilydene) cyclopentanone via Claisen Schmidt Condensation Reaction. Prosiding Seminar Internasional. Yogyakarta: Universitas Gadjah Mada.

DOI: https://doi.org/10.20961/jpscr.v1i2.1942

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