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Determination Stability of 99mTc-Etambutol Radiopharmaceuticals for Tuberculosis Detected


 
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1. Title Title of document Determination Stability of 99mTc-Etambutol Radiopharmaceuticals for Tuberculosis Detected
 
2. Creator Author's name, affiliation, country Anna Roseliana; Pusat Teknologi Radioisotop dan Radiofarmaka (PTRR)-BATAN Jl. Kawasan PUSPIPTEK Serpong, Gedung 11, Tangerang Selatan, Banten 15314; Indonesia
 
2. Creator Author's name, affiliation, country Witarti Witarti; Pusat Teknologi Radioisotop dan Radiofarmaka (PTRR)-BATAN Jl. Kawasan PUSPIPTEK Serpong, Gedung 11, Tangerang Selatan, Banten 15314; Indonesia
 
2. Creator Author's name, affiliation, country Enny Lestari; Pusat Teknologi Radioisotop dan Radiofarmaka (PTRR)-BATAN Jl. Kawasan PUSPIPTEK Serpong, Gedung 11, Tangerang Selatan, Banten 15314; Indonesia
 
2. Creator Author's name, affiliation, country Maula Eka Sriyani; Pusat Sains dan Teknologi Nuklir Terapan (PSTNT)-BATAN Jl. Taman Sari No.71, Bandung, Jawa Barat 40132; Indonesia
 
2. Creator Author's name, affiliation, country Widyastuti Widjaksana; Pusat Sains dan Teknologi Nuklir Terapan (PSTNT)-BATAN Jl. Taman Sari No.71, Bandung, Jawa Barat 40132; Indonesia
 
3. Subject Discipline(s)
 
3. Subject Keyword(s) radiopharmaceuticals; ethambutol kit; detection; tuberculosis; stability
 
4. Description Abstract

99mTc-ethambutol radiopharmaceutical is a diagnostic kit based on the anti-tuberculosis drug, ethambutol, labeled with radioactive tracer 99mTc.  This radiopharmaceutical is a result of research development in Centre for Radioisotope and Radiopharmaceutical Technology, BATAN. 99mTc-ethambutol radiopharmaceutical in the hospital used as a diagnostic agent for tuberculosis detected, particularly tuberculosis in extra pulmonary organs that is not easily detected by existing  conventional methods. The aim of study to find out how stable ethambutol kit when stored at certain temperature and how stable ethambutol stability after labelled  with 99mTc.  These stability data are required by hospitals which used 99mTc-ethambutol . The stability test performed by measuring the radiochemical purity of  ethambutol kits which were stored at certain time period and labelled with 99mTc using thin layer chromatography (TLC) method. Radiochemical purity tests were also performed on 99mTc-ethambutol at certain time period after its labeling process.  Based on experiment results, it was obtained that ethambutol kit was still stable for up to 9 months when stored at refrigerator temperature 8 oC with percentage of radiochemical purity average > 85% and up to 11 months when stored in deep freezer temperature -80 oC with percentage of radiochemical purity average 90%. While 99mTc-ethambutol was still stable for up to 4 hours after labeling with  percentage of radiochemical purity more than > 85%.

 
5. Publisher Organizing agency, location Program Studi Pendidikan Kimia FKIP Universitas Sebelas Maret
 
6. Contributor Sponsor(s)
 
7. Date (YYYY-MM-DD) 2019-04-30
 
8. Type Status & genre Peer-reviewed Article
 
8. Type Type
 
9. Format File format PDF
 
10. Identifier Uniform Resource Identifier https://jurnal.uns.ac.id/jkpk/article/view/22364
 
10. Identifier Digital Object Identifier https://doi.org/10.20961/jkpk.v4i1.22364
 
11. Source Title; vol., no. (year) JKPK (Jurnal Kimia dan Pendidikan Kimia); Vol 4, No 1 (2019): JKPK ( Jurnal Kimia dan Pendidikan Kimia)
 
12. Language English=en en
 
13. Relation Supp. Files Untitled (301KB)
 
14. Coverage Geo-spatial location, chronological period, research sample (gender, age, etc.)
 
15. Rights Copyright and permissions Copyright (c) 2019 JKPK (Jurnal Kimia dan Pendidikan Kimia)