The Study Utilization of Mangosteen (Garcinia mangostana L.) Peel Extract as a Gel-Based Burn Wound Plaster

Kalimaya Qolbi Sani, Paulina Paulina, Priyanka Khansa Insyira

Abstract

Abstract. The industry in Indonesia is currently experiencing significant development dominated by workers in the informal sector. During the business/production processes, problems are often encountered, leading to injuries or wounds. Burn wound are caused by heat sources such as fire, electricity, hazardous chemicals, and radiation. One natural substance with the potential to be used as an alternative treatment for burn wound is mangosteen peel. Mangosteen peel contains active biochemical compounds, including flavonoids, tannins, xanthones, and alkaloid derivatives, which have anti-inflammatory effects that can aid in the wound healing process by promoting collagen formation. Additionally, the presence of saponins in mangosteen peel makes it antibacterial. This research aims to explore the potential of mangosteen peel patches in the healing of burn injuries often experienced by informal industrial workers. The research method used secondary data through a literature review study. Article searches were conducted using keywords such as 'wound' and 'mangosteen peel.' Through the analysis of 10 articles, it was found that mangosteen peel has great potential to be utilized as a mangosteen peel patch, with a wound healing percentage of up to 83% over 21 days at an optimum concentration of 15%. The availability of patches made from mangosteen peel extract (Garcinia mangostana L.) is expected to assist informal workers or UMKM in addressing burn wound they may encounter during work while also helping to utilize waste that would otherwise go unused.

Keywords:

Biochemical compounds, Burn wound, Informal Sector, Mangosteen Peel, Plaster

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References

[1] A.N. Rahmi, Perkembangan industri ekonomi kreatif dan pengaruhnya terhadap perekonomian di indonesia, in: Seminar Nasional Sistem Informasi (SENASIF), 2018: pp. 1386–1395.

[2] Y. Yunanto, “Analisis Kesiapan Daya Saing Industri Kecil Menengah (IKM) Hanmade Industri Sepatu Kabupaten Magetan Menghadapi Era Globalisasi (Studi Kasus Hanmade Industri Sepatu Kabupaten Magetan),” Jurnal Penelitian Manajemen Terapan (PENATARAN). 1 12–22 (2016).

[3] I.M. Ramdan, “Memperbaiki kondisi kesehatan dan keselamatan kerja sektor informal melalui program corporate social responsibility perusahaan,” Jurnal Manajemen Pelayanan Kesehatan. 15 2–6 (2012).

[4] R. Hadiyanti, M. Setiawardani, “Pengaruh pelaksanaan program keselamatan dan kesehatan kerja terhadap produktivitas kerja karyawan,” Jurnal Riset Bisnis Dan Investasi. 3 12–23 (2017).

[5] N. Asilah, M. Catur Yuantari, “Analisis Faktor Kejadian Kecelakaan Kerja pada Pekerja Industri Tahu,” Jurnal Ilmu Kesehatan Masyarakat (2020). https://journal.unnes.ac.id/sju/index.php/jppkmiURL:https://journal.unnes.ac.id/sju/index.php/jppkmi/article/view/41434/173.

[6] P.A. Suratmini, I.G.A.A.K. Wardani, N.M.D.S. Suena, “Potensi Tanaman Obat terhadap Epitelisasi dalam Penyembuhan Luka Bakar,” Usadha: Jurnal Integrasi Obat Tradisional. 1 (2021).

[7] M.L. Ramdani, Peningkatan pengetahuan bahaya luka bakar dan P3K kegawatan luka bakar pada anggota Ranting Aisyiyah, in: Prosiding Seminar Nasional LPPM UMP, 2019: pp. 103–106.

[8] E. Yatman, “Kulit Buah Manggis Mengandung Xanton Yang Berkhasiat Tinggi,”Jurnal Ilmiah Widya.. (2012)

[9] P.A.C. Wulandari, Z.N. Ilmi, S.A. Husen, D. Winarni, M.A. Alamsjah, K. Awang, M. Vastano, A. Pellis, D. Macquarrie, P. Pudjiastuti, “Wound healing and antioxidant evaluations of alginate from sargassum ilicifolium and mangosteen rind combination extracts on diabetic mice model,” Applied Sciences (Switzerland). 11 (2021). https://doi.org/10.3390/app11104651.

[10] D.W. Rahayuningdyah, “Pengembangan Formula Hidrogel Balutan Luka Menggunakan Kombinasi Polimer Galaktomanan dan PVP,” Pharmaceutical Journal of Indonesia. 5 117–122 (2020).

[11] T. Martati, G. Devita, Aktivitas Penangkap Radikal Bebas Ekstrak Etanol Kulit Buah Naga Dengan Metode Dpph (1, 1-Difenil-2-Pikrilhidrazil), in: Proceeding of Mulawarman Pharmaceuticals Conferences, 2016: pp. 430–439.

[12] F.M. Tarmidzi, I.K. Maharsih, T.R. Jannah, C.S. Wahyuni, “Sintesis Hidrogel Pektin–Gelatin dengan Penambahan Ekstrak Kulit Buah Naga Sebagai Kandidat Pembalut Luka Bakar,” Jurnal Teknik Kimia Dan Lingkungan. 4 53–60 (2020).

[13] A.N.I. Adriana, “Pengaruh Pemberian Topikal Gel Ekstrak Kulit Buah Manggis (Garcinia mangostana L.) Terhadap Penyembuhan Luka Bakar (Vulnus combustion) Pada Kelinci (Oryctolagus cuniculus),” Fito Medicine: Journal Pharmacy and Sciences. 14 1–8 (2022).

[14] Y.V.P. Aryati, I. Setiawan, N.R. Ariani, D.D. Hastuti, “Pengaruh Gel Kombinasi Ekstrak Kulit Semangka (Citrullus Lanatus (Thunb.)) Dan Ekstrak Kulit Manggis (Garcinia Mangostana L.) Terhadap Penyembuhan Luka Bakar Pada Kelinci,” Indonesian Journal On Medical Science. 6 (2019).

[15] M.E. Pangow, “Skrining Fitokimia dan Uji Toksisitas dari Ekstrak Etanol Daun Manggis (Garcinia mangostana L.) dengan Metode Brine Shrimp Lethality Test (BSLT),” Pharmacon. 7 (2018).

[16] A.R. Biran, S. Chairani, S.R.P. Dewi, “Efek Ekstrak Kulit Manggis (Garcinia Mangostana L.) Terhadap Pembentukan Pembuluh Darah Baru Pada Luka Gingiva Tikus Wistar,” Jurnal’Aisyiyah Medika. 3 (2019).

[17] T. Noverita Khairani, R. Mayana Rumanti, A. Manao, “Formulasi Sediaan Krim Ekstrak Etanol Kulit Buah Manggis (Garcinia mangostana L.) Sebagai Obat Luka Bakar Pada Tikus Putih Jantan,” Jurnal Dunia Farmasi. (2020).

[18] L. Kusmita, I. Puspitaningrum, F. Famasi, Uji Aktivitas Gel Ekstrak Etanol Kulit Buah Manggis (Garcinia mangostana L.) Sebagai Penyembuh Luka Bakar Pada Kulit Punggung Kelinci”, Media Farmasi Indonesia. (2014)

[19] N. Wathoni, D.P. Sari, I. Suharyani, K. Motoyama, A.F.A. Mohammed, A. Cahyanto, M. Abdassah, M. Muchtaridi, “Enhancement of α-mangostin wound healing ability by complexation with 2-hydroxypropyl-β-cyclodextrin in hydrogel formulation,” Pharmaceuticals. 13 1–16 (2020). https://doi.org/10.3390/ph13100290.

[20] H.B. Sombolayuk, K. Djawad, S. Wahab, U.A. Miskad, G. Alam, I. Pattelongi, “The effectivity of topical mangosteen pericarp extract cream on wound healing in Swiss albino mice,” Journal of Biological Research (Italy). 92 (2019). https://doi.org/10.4081/jbr.2019.8150.

[21] D. Dira, Y. Yanuarista, R. Afrianti, “Uji Aktivitas Ekstrak Pericarp Kulit Buah Manggis Terpurifikasi Dalam Penyembuhan Luka Eksisi,” Talenta Conference Series: Tropical Medicine (TM). 1 134–138 (2018). https://doi.org/10.32734/tm.v1i3.278.

[22] N. Sugihartini, R.Y. Wiradhika, “Gel formulation of ethanol extract of mangosteen peel (Garcinia mangostana L.) as a medication for burns in wistar rats,” JKKI: Jurnal Kedokteran Dan Kesehatan Indonesia. 110–117 (2017).

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