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Riboflavin (vitamin B2) plays an important role in the growth and maintenance of human metabolism. Riboflavin is the highly sensitive and unstable to environmental influences such as light, reducing agents and pH. Riboflavin is protected by forming it into microcapsules with sodium alginate as a matrix and coated with chitosan reinforced with glutraldehid crosslinking. This study aims to study the process of microencapsulation of riboflavin with sodium alginate and chitosan and is emphasized to study the effect surfactant span 80 upon the size of the microcapsules formed. Based on microcapsule size and its distribution, it can be concluded that more span 80 added to paraffin oil will reduce the size of microcapsule that is formed
Chan, L.W., Jin, Y., and Heng, P.W.S., “Crosslinking Mechanisms of Calcium and Zinc in Production of Alginate Microspheres”, Int. J. Pharmacetuics, 242, pp. 255-258, 2002
Grant, G.T., Morris, E.R., and Rees, D.A., “Biological Interactions Between Polysaccharides and
Divalent Cations : The Egg-Box Model”, FEBS Letters, Vol. 32, No.1, pp. 195-198, 1973
Rastogi, R., Sultana, Y., Aqil, M., Ali, A., Kumar, S., Chuttani, K., and Mishra, A.K., “Alginate
Microspheres of Isoniazid for Oral Sustained Drug Delivery”, Int. J. Pharmaceutics, 334, pp. 71-77, 2007 [4] Liu, P. and Krishnan, T.R., “Alginate-Pectin-Poly-L-lysine Particulates as a Potential Controlled Release
Formulation”, J. Pharm. Pharmacol., 51, pp.141-149, 1999
Finotelli, P.V., Silva, D.D., Sola-Penna, M., Rossi, A.M., Farina, M., Andrade, L.R., Takeuchi, A.Y., and Rocha-Leao,M.H., “Microcapsule of Alginat/Chitosan Containing Magnetic Nanoparticles for Controlled Release of Insulin”, Colloids and Surfaces B : Biointerfaces, 81, pp.206-211, 2010
Polk, A., Amsden, B., De Yao, K., Peng, T., and Goosen, M.F.A., “Controlled Release of Albumin from Chitosan-Alginate Microcapsule”, Journal of Pharmaceutical Sciences, Vol. 83, No. 2, pp. 178-185