Gambaran Klinis Telinga Hidung Tenggorokan Pasien SARS CoV-2 di RSUD Dr. Moewardi

Dewi Pratiwi, Hadi Sudrajad, Sarwastuti Hendradewi, Made Setiamika, Putu Wijaya Kandhi, Novi Primadewi, Vicky Eko Nurcahyo Hariyadi, Adisetya Wicaksono, Marisa Rizqiana Dewi

Abstract

ABSTRAK

Pendahuluan: COVID-19 merupakan infeksi yang disebabkan oleh SARS-CoV-2. Prevalensi kasus COVID-19 di Indonesia pada akhir tahun 2020 mencapai 750.000 kasus dan terus meningkat hingga saat ini. Manifestasi klinis yang dialami oleh pasien COVID-19 cukup beragam. Tujuan penelitian ini adalah untuk mengetahui gambaran klinis telinga hidung tenggorokan (THT) pasien SARS CoV-2 di RSUD Dr. Moewardi Surakarta.

Metode: Penelitian cross-sectional melibatkan 316 pasien terkonfirmasi SARS-CoV-2 positif di RSUD Dr. Moewardi, Surakarta, Jawa Tengah selama April sampai Juni 2021. Dilakukan pemeriksaan PCR untuk melihat status infeksi SARS-CoV-2 dan anamnesis untuk melihat gambaran klinis telinga hidung tenggorokan pasien menggunakan kuesioner. Data univariat dianalisis secara deskriptif kuantitatif dan disajikan dalam bentuk distribusi frekuensi.

Hasil: Secara umum, distribusi empat gejala THT terbanyak pada pasien terinfeksi SARS-CoV-2 berturut-turut adalah nyeri tenggorok (21.52%), hilang penciuman (11.71%), hilang rasa pengecapan (10.44%), dan hidung tersumbat (9.18%). Gejala non-THT yang terbanyak ditemukan meliputi demam (73.73%) dan batuk (57.91%). Keempat gejala THT terbanyak tersebut juga ditemukan pada usia 15-64 tahun, kecuali pada usia ≥65 tahun dimana gejala sakit kepala (3.17%) merupakan gejala terbanyak kedua setelah nyeri tenggorok. Tidak ditemukan gejala hidung tersumbat pada usia ≥65 tahun. Gejala THT terbanyak pada pasien pria terinfeksi SARS-CoV-2 berturut-turut adalah nyeri tenggorok (9.82%), hilang penciuman (4.75%), hidung tersumbat (4.44%), dan hilang pengecapan (2.85%). Sementara itu, gejala THT terbanyak pada wanita terinfeksi SARS-CoV-2 berturut-turut meliputi nyeri tenggorok (11.07%), hilang pengecapan (7.59%), hilang penciuman (6.96%), dan hidung tersumbat (4.74%).

Kesimpulan: Gambaran klinis telinga hidung tenggorokkan pasien terinfeksi SARS-CoV-2 yang paling sering muncul berturut-turut adalah nyeri tenggorok, hilang penciuman, hilang pengecapan, dan hidung tersumbat. Frekuensi gejala ini bervariasi akibat banyak faktor, diantaranya adalah umur dan jenis kelamin.

Keywords

SARS CoV-2; deteksi dini; gejala klinis THT; anosmia; dysgeusia

Full Text:

PDF

References

LM W, X S, XQ W. Pain Symptoms in Patients with Coronavirus Disease (COVID-19): A Literature Review. J Pain Res [Internet]. 2021 [cited 2021 Jul 24];14:147–59. Available from: https://pubmed.ncbi.nlm.nih.gov/33531833/ 2. WHO Coronavirus (COVID-19) Dashboard | WHO Coronavirus (COVID-19) Dashboard With Vaccination Data [Internet]. [cited 2021 Jul 24]. Available from: https://covid19.who.int/ 3. Guan W, Ni Z, Hu Y, Liang W, Ou C, He J, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. https://doi.org/101056/NEJMoa2002032 [Internet]. 2020 Feb 28 [cited 2021 Jul 24];382(18):1708–20. Available from: https://www.nejm.org/doi/full/10.1056/nejmoa2002032 4. He X, Cheng X, Feng X, Wan H, Chen S, Xiong M. Clinical Symptom Differences Between Mild and Severe COVID-19 Patients in China: A Meta-Analysis. Front Public Heal. 2021 Jan 14;0:954. 5. Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China. JAMA [Internet]. 2020 Mar 17 [cited 2021 Jul 24];323(11):1061–9. Available from: https://jamanetwork.com/journals/jama/fullarticle/2761044 6. R K, CWD C, K K, J B, JC D. COVID-19 Anosmia Reporting Tool: Initial Findings. Otolaryngol Head Neck Surg [Internet]. 2020 Jul 1 [cited 2021 Jul 24];163(1):132–4. Available from: https://pubmed.ncbi.nlm.nih.gov/32340555/ 7. MW E-A, S E, YA F. ENT manifestation in COVID-19 patients. Auris Nasus Larynx [Internet]. 2020 Aug 1 [cited 2021 Jul 24];47(4):559–64. Available from: https://pubmed.ncbi.nlm.nih.gov/32586739/ 8. Sakalli E, Temirbekov D, Bayri E, Alis EE, Erdurak SC, Bayraktaroglu M. Ear nose throat-related symptoms with a focus on loss of smell and/or taste in COVID-19 patients. Am J Otolaryngol [Internet]. 2020 Nov 1 [cited 2021 Jul 24];41(6):102622. Available from: /pmc/articles/PMC7309902/ 9. Bojanowski V, Hummel T. Retronasal perception of odors. Physiol Behav. 2012 Nov 5;107(4):484–7. 10. Z W, B Y, Q L, L W, R Z. Clinical Features of 69 Cases With Coronavirus Disease 2019 in Wuhan, China. Clin Infect Dis [Internet]. 2020 Aug 1 [cited 2021 Jul 24];71(15):769–77. Available from: https://pubmed.ncbi.nlm.nih.gov/32176772/ 11. Cortis D. On Determining the Age Distribution of COVID-19 Pandemic. Front Public Heal. 2020 May 15;0:202. 12. [The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China]. Zhonghua Liu Xing Bing Xue Za Zhi [Internet]. 2020 Feb 1 [cited 2021 Jul 24];41(2):297–300. Available from: https://pubmed.ncbi.nlm.nih.gov/32064853/ 13. Cascella M, Rajnik M, Aleem A, Dulebohn SC, Napoli R Di. Features, Evaluation, and Treatment of Coronavirus (COVID-19). StatPearls [Internet]. 2021 Jul 17 [cited 2021 Jul 24]; Available from: https://www.ncbi.nlm.nih.gov/books/NBK554776/ 14. Savtale S, Hippargekar P, Bhise S, Kothule S. Prevalence of Otorhinolaryngological Symptoms in Covid 19 Patients. Indian J Otolaryngol Head Neck Surg [Internet]. 2021 [cited 2021 Jul 24];1. Available from: /pmc/articles/PMC7869773/ 15. Patil KI. Otorhinolaryngological Manifestations in COVID-19 Patients. Sch J Otolaryngol. 2020 Oct 5;5(3). 16. Wolford RW, Goyal A, Syed SYB, Schaefer TJ. Pharyngitis. Netter’s Infect Dis [Internet]. 2021 May 7 [cited 2021 Jul 24];177–82. Available from: https://www.ncbi.nlm.nih.gov/books/NBK519550/ 17. R E. Understanding the symptoms of the common cold and influenza. Lancet Infect Dis [Internet]. 2005 Nov [cited 2021 Jul 24];5(11):718–25. Available from: https://pubmed.ncbi.nlm.nih.gov/16253889/ 18. JS O, M L. Acute sore throat revisited: clinical and experimental evidence for the efficacy of over-the-counter AMC/DCBA throat lozenges. Int J Clin Pract [Internet]. 2011 May [cited 2021 Jul 24];65(5):524–30. Available from: https://pubmed.ncbi.nlm.nih.gov/21489076/ 19. Han AY, Mukdad L, Long JL, Lopez IA. Anosmia in COVID-19: Mechanisms and Significance. Chem Senses [Internet]. 2020 Jul 7 [cited 2021 Jul 24];45(6):423–8. Available from: https://academic.oup.com/chemse/article/45/6/423/5859163 20. Lee Y, Min P, Lee S, Kim S-W. Prevalence and Duration of Acute Loss of Smell or Taste in COVID-19 Patients. J Korean Med Sci [Internet]. 2020 Mar 3 [cited 2021 Jul 24];35(18). Available from: https://doi.org/10.3346/jkms.2020.35.e174 21. Ibekwe TS, Fasunla AJ, Orimadegun AE. Systematic Review and Meta-analysis of Smell and Taste Disorders in COVID-19: https://doi.org/101177/2473974X20957975 [Internet]. 2020 Sep 11 [cited 2021 Jul 24];4(3). Available from: https://journals.sagepub.com/doi/full/10.1177/2473974X20957975 22. Chaurasia P, Kuchhal V, Ahmad S, Rawat P. ENT manifestations in Covid-19 positive patients. Int J Heal Clin Res [Internet]. 2020 Nov 30 [cited 2021 Jul 24];3(10):187–91. Available from: https://www.ijhcr.com/index.php/ijhcr/article/view/391 23. LA V, G S, G D, G DR. Anosmia and Ageusia: Common Findings in COVID-19 Patients. Laryngoscope [Internet]. 2020 Jul 1 [cited 2021 Jul 24];130(7):1787. Available from: https://pubmed.ncbi.nlm.nih.gov/32237238/ 24. El-Radhi AS. Pathogenesis of Fever. Clin Man Fever Child [Internet]. 2018 [cited 2021 Jul 24];53. Available from: /pmc/articles/PMC7122269/ 25. Grant MC, Geoghegan L, Arbyn M, Mohammed Z, McGuinness L, Clarke EL, et al. The prevalence of symptoms in 24,410 adults infected by the novel coronavirus (SARS-CoV-2; COVID-19): A systematic review and meta-analysis of 148 studies from 9 countries. PLoS One [Internet]. 2020 Jun 1 [cited 2021 Jul 24];15(6):e0234765. Available from: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234765 26. Song W-J, Hui CKM, Hull JH, Birring SS, McGarvey L, Mazzone SB, et al. Confronting COVID-19-associated cough and the post-COVID syndrome: role of viral neurotropism, neuroinflammation, and neuroimmune responses. Lancet Respir Med [Internet]. 2021 May 1 [cited 2021 Jul 24];9(5):533–44. Available from: http://www.thelancet.com/article/S2213260021001259/fulltext 27. M M, H S, A P, J S, P G, P C, et al. A Meta-Analysis of 67 Studies with Presenting Symptoms and Laboratory Tests of COVID-19 Patients. Laryngoscope [Internet]. 2021 Jun 1 [cited 2021 Jul 24];131(6):1254–65. Available from: https://pubmed.ncbi.nlm.nih.gov/33068023/ 28. A N-P, SR A-S, LM K, M C, S T, K W-T. COVID 19 - Clinical Picture in the Elderly Population: A Qualitative Systematic Review. Aging Dis [Internet]. 2020 [cited 2021 Jul 24];11(4):988–1008. Available from: https://pubmed.ncbi.nlm.nih.gov/32765959/ 29. A B, A B, F K, O D, S M, Z O. Olfactory and Oral Manifestations of COVID-19: Sex-Related Symptoms-A Potential Pathway to Early Diagnosis. Otolaryngol Head Neck Surg [Internet]. 2020 Oct 1 [cited 2021 Jul 24];163(4):722–8. Available from: https://pubmed.ncbi.nlm.nih.gov/32539587/

Refbacks

  • There are currently no refbacks.