Potential Significance of Neural Stem Cell-Based Therapy for Future Clinical Practice

Muthmainah Muthmainah

Abstract

Introduction: Disorders of the central nervous system contribute to long-term disabilities. Current treatments have not been able to fully replace the damaged tissue and dysfunctional neurons. Treatment options aiming at driving both structural and functional repair of neuronal tissue such as neural stem cells therapy has attracted many researcher. This narrative review aims to examine the therapeutic potential of neural stem cells and highlights some of the challenges in harnessing NSCs use into clinical practice.

Methods: Two database including Pubmed and Scopus were used for literature search. Relevant studies were included in the review.

Results: Both exogenous stem cell transplantation and endogenous neurogenesis seem to show potential for the treatment of several neurological disorders.However, several challenges remain with regards to the translation of neural stem cells therapy into clinical practice.

Conclusion: Neural stem cell-based therapy provides great potential for future clinical practice. However, further research is required to ensure the clinical efficacy and efficiency in delivering the therapy.

Keywords

neurogenesis; neural stem cell; translational research; neurodegeneration; brain injury

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References

  1. Raj R, Kaprio J, Korja M, Mikkonen ED, Jousilahti P, Siironen J. Risk of hospitalization with neurodegenerative disease after moderate-to-severe traumatic brain injury in the working-age population: a retrospective cohort study using the Finnish national health registries. PLoS medicine. 2017 Jul 5;14(7):e1002316.
  2. Gögel S, Gubernator M, Minger SL. Progress and prospects: stem cells and neurological diseases. Gene therapy. 2011 Jan;18(1):1-6.
  3. Lee Y, Boschian C, Ko K. MicroRNA-mediated regulation of proliferation, lineage differentiation, and apoptosis in neural stem cells. RNA biology. 2025 Dec 31;22(1):1-7.
  4. Horie N. Neural Stem Cells/Neuronal Progenitor Cells. Cell Therapy Against Cerebral Stroke: Comprehensive Reviews for Translational Researches and Clinical Trials. 2017 Jan 7:27-37.
  5. Huang J, Cai H, Zhu Z, Zhang G, Zhang Y, Li R, et al. Exosomes derived from neural stem cells regulates neural stem cells and applicates in nervous system diseases. Chinese Journal of Neuromedicine. 2023:826-32.
  6. Leung JW, Cheung KK, Ngai SP, Tsang HW, Lau BW. Protective effects of melatonin on neurogenesis impairment in neurological disorders and its relevant molecular mechanisms. International journal of molecular sciences. 2020 Aug 6;21(16):5645.
  7. Kim HJ, Sun W. Adult neurogenesis in the central and peripheral nervous systems. International Neurourology Journal. 2012 Jun 30;16(2):57.
  8. Abbott LC, Nigussie F. Adult neurogenesis in the mammalian dentate gyrus. Anatomia, histologia, embryologia. 2020 Jan;49(1):3-16.
  9. Evans A, Terstege DJ, Scott GA, Tsutsui M, Epp JR. Neurogenesis mediated plasticity is associated with reduced neuronal activity in CA1 during context fear memory retrieval. Scientific Reports. 2022 Apr 29;12(1):7016.
  10. Cope EC, Gould E. Adult neurogenesis in the hippocampus: A role in learning and memory. InThe Curated Reference Collection in Neuroscience and Biobehavioral Psychology 2016 Jan 1 (pp. 345-358). Elsevier Science Ltd..
  11. Leuner B, Gould E, Shors TJ. Is there a link between adult neurogenesis and learning?. Hippocampus. 2006;16(3):216-24.
  12. Siteneski A, Olescowicz G, Pazini FL, Camargo A, Fraga DB, Brocardo PS, Gil-Mohapel J, Cunha MP, Rodrigues AL. Antidepressant-like and pro-neurogenic effects of physical exercise: the putative role of FNDC5/irisin pathway. Journal of neural transmission. 2020 Mar;127(3):355-70.
  13. Bhagya VR, Srikumar BN, Veena J, Shankaranarayana Rao BS. Short‐term exposure to enriched environment rescues chronic stress‐induced impaired hippocampal synaptic plasticity, anxiety, and memory deficits. Journal of Neuroscience Research. 2017 Aug;95(8):1602-10.
  14. Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, Dulawa S, Weisstaub N, Lee J, Duman R, Arancio O, Belzung C. Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. science. 2003 Aug 8;301(5634):805-9.
  15. Zhao C, Deng W, Gage FH. Mechanisms and functional implications of adult neurogenesis. Cell. 2008 Feb 22;132(4):645-60.
  16. Kim JY, Shaker MR, Lee JH, Lee B, Kim H, Sun W. Identification of molecular markers distinguishing adult neural stem cells in the subventricular and subcallosal zones. Animal cells and systems. 2017 May 17;21(3):152-9.
  17. Arvidsson A, Collin T, Kirik D, Kokaia Z, Lindvall O. Neuronal replacement from endogenous precursors in the adult brain after stroke. Nature medicine. 2002 Sep;8(9):963-70.
  18. Cuartero MI, García-Culebras A, Torres López C, Moro MA. Post-stroke neurogenesis: friend or foe? Front Cell Dev Biol. 2021 Mar 22;9:657846.
  19. Ceanga M, Dahab M, Witte OW, Keiner S. Adult neurogenesis and stroke: a tale of two neurogenic niches. Front Neurosci. 2021; 15: 700297
  20. Borlongan CV, Hess DC. New hope for stroke patients: mobilization of endogenous stem cells. Canadian Medical Association Journal. 2006 Mar 28;174(7):954-5.
  21. Fauzi AA, Thamrin AM, Permana AT, Ranuh IA, Hidayati HB, Hamdan M, Wahyuhadi J, Suroto NS, Lestari P, Chandra PS. Comparison of the administration route of stem cell therapy for ischemic stroke: a systematic review and meta-analysis of the clinical outcomes and safety. Journal of Clinical Medicine. 2023 Apr 6;12(7):2735.
  22. Li W, Shi L, Hu B, Hong Y, Zhang H, Li X, Zhang Y. Mesenchymal stem cell-based therapy for stroke: current understanding and challenges. Frontiers in Cellular Neuroscience. 2021 Feb 9;15:628940.
  23. Lalu MM, Montroy J, Dowlatshahi D, Hutton B, Juneau P, Wesch N, Y. Zhang S, McGinn R, Corbett D, Stewart DJ, A. Fergusson D. From the lab to patients: a systematic review and meta-analysis of mesenchymal stem cell therapy for stroke. Translational stroke research. 2020 Jun;11(3):345-64.
  24. Zhao LR, Willing A. Enhancing endogenous capacity to repair a stroke-damaged brain: An evolving field for stroke research. Progress in neurobiology. 2018 Apr 1;163:5-26.
  25. Luo Z, Shangguan Z, Cao L, Zhang Y, Li Q, Shi X, Fu J, Wang C, Dou X, Tan W, Li Q. Cerebrospinal fluid-contacting neurons: a promising source for adult neural stem cell transplantation in spinal cord injury treatment. Frontiers in Cell and Developmental Biology. 2025 Mar 12;13:1549194.
  26. Tang Y, Yu P, Cheng L. Current progress in the derivation and therapeutic application of neural stem cells. Cell death & disease. 2017 Oct;8(10):e3108-.
  27. Shah AJ, Dar MY. Jan B, et al. Neural Stem Cell Therapy for Alzheimer’s Disease: A-State-of-the-Art Review. Journal of Dementia and Alzheimer's Disease. 2024;1(2), 109-25.
  28. Master Z, McLeod M, & Mendez I. Benefits, risks and ethical considerations in translation of stem cell research to clinical applications in Parkinson’s disease. Journal of Medical Ethics. 2007;33(3): 69–173.
  29. Wei L, Yan W, Shah, W, et al. Advancements and challenges in stem cell transplantation for regenerative medicine. Heliyon. 2024;10(16):e35836.
  30. Brianna APK, Wong YP. Applying stem cell therapy in intractable diseases: a narrative review of decades of progress and challenges. Stem Cell Investig. 2022;9:4
  31. Muir KW, Bulters D, Willmot M, Sprigg N, Dixit A, Ward N, et al. Intracerebral implantation of human neural stem cells and motor recovery after stroke: multicentre prospective single-arm study (PISCES-2). J Neurol Neurosurg Psychiatry. 2020 Aug;91(8):855-862.

DOI: https://doi.org/10.13057/smj.v9i2.126364

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