IDIOPATHIC INFLAMMATORY MYOPATHY/MYOSITIS

Abstract

ABSTRACT

Introduction: Myopathy inflammation idiopathic (IIM) is a rare autoimmune disorder characterized by muscle weakness, proximal and symmetrical weakness, except distal and asymmetric weakness in inclusion body myositis (IBM). The diagnosis is based on clinical examination, laboratory tests, increased creatine kinase (CK) and autoantibodies, electromyography (EMG), and histopathology. Extramuscular involvement can influence cases like lungs interstitial (ILD), dermatomyositis skin (DM), systemic or joints, and increases the risk of malignancy, especially in DM. Treatment is mainly immunosuppressive, with most cases requiring more than one agent. Line drugs include mycophenolate mofetil, cyclosporine, tacrolimus, rituximab, etanercept, and cyclophosphamide.

Conclusion: Myositis, a rare disorder, can be differentiated into four forms: DM, PM, N A M, and IBM. Treatment is largely based on experience, with IBM remaining a challenge due to its complex pathogenesis. Developing new treatments is justified due to growing interest in rare disorders.

Keywords: Idiopathic Inflammatory Myopathy, Myositis