The Effect of Snail Mucus (Achatina Fulica) on The Degree of Kidney Interstitial Fibrosis In Lupus Nephritis Mice Model

Arief Nurudhin, Zainal Arifin Adnan, Yulyani Werdiningsih, Nurhasan Agung Prabowo, Fathina Nisa Rabbani

Abstract

Introduction:cytotoxic drugs dominate SLE therapy, so new therapies with minimum side effects are needed. Snail (Achatina Fulica) mucus contains two types of protein; heparan and acharan sulfate. The snail mucus has significant potential benefits, but its use in lupus nephritis has never been examined.

Methods:This research used an experimental model. It used mice for the experiment. The mice were divided into five groups: control, untreated lupus, standard therapy (methylprednisolone), snail mucus therapy, and a combination of standard therapy and snail mucus. Renal histology was examined at the end of the fifth month. Data were analyzed using the Shapiro-Wilk, ANOVA, and Tukey Post Hoc tests.

Results: The level of interstitial fibrosis between the standard therapy group and the snail mucus group showed an MD value of -0.13 with a p-value of 1.00, meaning there is no significant difference between the level of interstitial fibrosis in the two groups. The comparison between the standard therapy group and the combination of the standard therapy group showed an MD value of 0.64 with a p-value of 0.992, which means that the combination of standard therapy tends to decrease the level of interstitial fibrosis.  

Conclusion: The administration of snail mucus in combination with standard therapy affects the decrease in the level of interstitial fibrosis in mice model lupus.

Keywords

Achatina fulica; lupus nephritis; renal interstitial fibrosis; snail mucus

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DOI: https://doi.org/10.20961/tscm.v1i1.53930

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