The Effect of DHA and EPA on Skin Dryness and Arthritic Joint Pain in Patients with Sjögren’s Syndrome at Dr. Moewardi Hospital.

Songia Dwi Wijaya, Arief Nurudhin, Dyonisa Nasirochmi Pakha

Abstract

Songia Dwi Wijaya, G0021209. The Effect of DHA and EPA on Skin Dryness and Joint Pain in Arthritis Patients with Sjogren's Syndrome at Moewardi Hospital. Undergraduate Thesis. Faculty of Medicine, Sebelas Maret University, Surakarta. Background: Sjogren’s syndrome is an autoimmune disease that affects exocrine glands, causing dryness of the skin, eyes, and mouth, as well as joint pain. Conventional therapies mainly manage symptoms. Omega-3 fatty acids, particularly DHA and EPA, possess anti-inflammatory properties that may improve skin and joint conditions. This study aimed to determine the effects of DHA and EPA supplementation on skin dryness and joint pain in patients with Sjogren’s syndrome. Method: A randomized controlled trial with a pretest–posttest control group design was conducted on 44 Sjogren’s syndrome patients at Dr. Moewardi Hospital. Participants were divided into intervention (DHA + EPA) and control groups. The intervention group received DHA 500 mg and EPA 500 mg twice daily for two months. Skin dryness was assessed using the Overall Dry Skin (ODS) score and joint pain using the Numeric Rating Scale (NRS). Data were analyzed using the Wilcoxon Signed Rank and Mann–Whitney U tests. Result: The intervention group showed significant reductions in ODS (p = 0.000) and NRS (p = 0.000) scores, while the control group showed no significant changes (p > 0.05). Between-group analysis revealed significant differences (p < 0.05), indicating that DHA and EPA supplementation effectively reduced skin dryness and joint pain. Conclusion: DHA and EPA supplementation significantly improve skin dryness and reduce joint pain in patients with Sjogren’s syndrome, suggesting their potential as a safe and effective adjunct therapy to enhance patients’ quality of life. Keywords: DHA, EPA, Sjogren’s syndrome, dry skin, joint pain

Keywords

DHA EPA SJOGREN SYNDROM SKIN DRYNESS JOINT PAIN

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DOI: https://doi.org/10.20961/tscm.v3i3.112857

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