Background : Post dural puncture headache (PDPH) is a complication of the neuroaxial block anesthesia technique that cause leakage of cerebrospinal fluid (CSF) from a dural defect and intracranial hypotension. Typical symptoms, PDPH is bilateral, frontal, retroorbital or occipital headaches and extends into the neck constanly or slowly, and associated with photophobia and nausea.  Management treatment of PDPH starting from conventional therapy (non-pharmacological and pharmacological) and invasive therapy including transnasal sphenopalatine ganglion block and as a gold standar is epidural blood patch that more invasive. Transnasal sphenopalatine ganglion block is a minimally invasive procedure on sphenopalatine ganglion which is an extracranial parasympathetic ganglion at fossa pterygopalatine. Various research state that efficacy of sphenopalatine ganglion block better than epidural blood patch.

Case Illustration : Reported a female, 37 years old came with headache extend to neck dan was diagnosed with PDPH post caesarean section with subarachnoid block anesthesia. Conservative therapy has been done but there is no improvement. As the next step, the patient transnasal sphenopalatine ganglion block using lidocaine 2% 3cc. The day after therapy, there is no complaint, VAS was 0-1 without complications and patient was allowed dismiss from hospital.

Conclusion : Transnasal sphenopalatine ganglion block is an invasive procedure as PDPH therapy that is very rarely performed. This action can be performed if the patient has undergone conventional therapy and there has been no improvement. With this case report, we can see that the efficacy of this procedure is very good and it is recommended before an epidural blood patch is performed.