Extracorporeal Liver Support in Liver Failure: A Comprehensive Review of MARS, SPAD, Prometheus, ADVOS, and Bioartificial Systems
| Dublin Core | PKP Metadata Items | Metadata for this Document | |
| 1. | Title | Title of document | Extracorporeal Liver Support in Liver Failure: A Comprehensive Review of MARS, SPAD, Prometheus, ADVOS, and Bioartificial Systems |
| 2. | Creator | Author's name, affiliation, country | Meta Restu Synthana; Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Public Health, and Nursing, Gadjah Mada University, Yogyakarta; Indonesia |
| 2. | Creator | Author's name, affiliation, country | Akhmad Yun Jufan; Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Public Health, and Nursing, Gadjah Mada University, Yogyakarta; Indonesia |
| 2. | Creator | Author's name, affiliation, country | Calcarina Fitriani Retno Wisudarti; Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Public Health, and Nursing, Gadjah Mada University, Yogyakarta; Indonesia |
| 2. | Creator | Author's name, affiliation, country | Fiandila Elvana Deviatika; Faculty of Medicine, Public Health, and Nursing, Gadjah Mada University, Yogyakarta; Indonesia |
| 3. | Subject | Discipline(s) | |
| 3. | Subject | Keyword(s) | ADVOS; Albumin Dialysis; Bioartificial Liver; Liver failure; MARS; Prometheus; SPAD. |
| 4. | Description | Abstract | Background : Acute and chronic liver failure are life-threatening conditions often requiring liver transplantation as definitive therapy. To delay or substitute the need for transplantation, various extracorporeal liver support systems have been developed. This article aims to review current artificial and bioartificial liver support systems including the Molecular Adsorbent Recirculating System (MARS), Single Pass Albumin Dialysis (SPAD), Prometheus, ADVanced Organ Support (ADVOS), and Bioartificial Liver (BAL) devices. Discussion : MARS and SPAD utilize albumin-based dialysis to remove protein-bound and water-soluble toxins. Prometheus applies a fractionated plasma separation and adsorption approach, while ADVOS enables individualized acid-base correction. Bioartificial liver systems integrate hepatocyte bioreactors with plasma dialysis to provide more physiological metabolic support. While these systems show promise in improving clinical outcomes, long-term survival benefit remains under investigation. Conclusion : Extracorporeal liver support systems offer essential bridging and supportive therapies for patients with liver failure. Selection should be tailored to patient condition, therapeutic goals, and technology availability. |
| 5. | Publisher | Organizing agency, location | Fakultas Kedokteran Universitas Sebelas Maret Surakarta |
| 6. | Contributor | Sponsor(s) | |
| 7. | Date | (YYYY-MM-DD) | 2025-10-31 |
| 8. | Type | Status & genre | Peer-reviewed Article |
| 8. | Type | Type | |
| 9. | Format | File format | |
| 10. | Identifier | Uniform Resource Identifier | https://jurnal.uns.ac.id/SOJA/article/view/107158 |
| 10. | Identifier | Digital Object Identifier | https://doi.org/10.20961/soja.v5i2.107158 |
| 11. | Source | Title; vol., no. (year) | Solo Journal of Anesthesi, Pain and Critical Care (SOJA); Vol 5, No 2 (2025): October 2025 |
| 12. | Language | English=en | en |
| 13. | Relation | Supp. Files | |
| 14. | Coverage | Geo-spatial location, chronological period, research sample (gender, age, etc.) | |
| 15. | Rights | Copyright and permissions |
Copyright (c) 2025 Meta Restu Synthana, Akhmad Yun Jufan, Calcarina Fitriani Retno Wisudarti, Fiandila Elvana Deviatika https://creativecommons.org/licenses/by/4.0/ |
